Desmin

Desmin je protein, který často tvoří stavební podjednotky intermediárních filament III. typu.^[1] Vyskytuje se obvykle podél Z linie v sarkomeře svalových buněk, je tedy specifický pro svalovou tkáň. Protein byl poprvé popsán v roce 1976,^[2] poprvé izolován v roce 1977,^[3] gen byl naklonován v roce 1989,^[4] a první knockout myš s uměle vyřazeným genem pro desmin se narodila v roce 1996.^[5] Desmin se vyskytuje pouze u obratlovců, nicméně u ostatních organismů často nacházíme podobné homologické proteiny.^[6] Jedná se o protein o velikosti 52 kDa, který se vyskytuje v kosterní, hladké i srdeční svalovině.^[7]

Reference

V tomto článku byl použit překlad textu z článku desmin na anglické Wikipedii.

↑ http://www.proteinatlas.org/gene_info.php?ensembl_gene_id=ENSG00000175084&antibody_id=34
↑ Lazarides E, Hubbard BD. Immunological characterization of the subunit of the 100 A filaments from muscle cells. Proc. Natl. Acad. Sci. U.S.A.. 1976, s. 4344–8. DOI 10.1073/pnas.73.12.4344. PMID 1069986.
↑ Izant JG, Lazarides E. Invariance and heterogeneity in the major structural and regulatory proteins of chick muscle cells revealed by two-dimensional gel electrophoresis. Proc. Natl. Acad. Sci. U.S.A.. 1977, s. 1450–4. DOI 10.1073/pnas.74.4.1450. PMID 266185.
↑ Li ZL, Lilienbaum A, Butler-Browne G, Paulin D. Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene. 1989, s. 243–54. DOI 10.1016/0378-1119(89)90227-8. PMID 2673923.
↑ Costa ML, Escaleira R, Cataldo A, Oliveira F, Mermelstein CS. Desmin: molecular interactions and putative functions of the muscle intermediate filament protein. Braz. J. Med. Biol. Res.. 2004, s. 1819–30. DOI /S0100-879X2004001200007. PMID 15558188.
↑ Bär H, Strelkov SV, Sjöberg G, Aebi U, Herrmann H. The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation?. J. Struct. Biol.. 2004, s. 137–52. DOI 10.1016/j.jsb.2004.04.003. PMID 15477095.
↑ Li Z, Mericskay M, Agbulut O, Butler-Browne G, Carlsson L, Thornell LE, Babinet C, Paulin D. Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J. Cell Biol.. 1997, s. 129–44. DOI 10.1083/jcb.139.1.129. PMID 9314534.

[1] ttp://www.proteinatlas.org/gene_info.php?ensembl_gene_id=ENSG00000175084&antibody_id=34

[pmid1069986-2] Lazarides E, Hubbard BD. Immunological characterization of the subunit of the 100 A filaments from muscle cells. Proc. Natl. Acad. Sci. U.S.A.. 1976, s. 4344–8. DOI 10.1073/pnas.73.12.4344. PMID 1069986.

[pmid266185-3] Izant JG, Lazarides E. Invariance and heterogeneity in the major structural and regulatory proteins of chick muscle cells revealed by two-dimensional gel electrophoresis. Proc. Natl. Acad. Sci. U.S.A.. 1977, s. 1450–4. DOI 10.1073/pnas.74.4.1450. PMID 266185.

[pmid2673923-4] Li ZL, Lilienbaum A, Butler-Browne G, Paulin D. Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene. 1989, s. 243–54. DOI 10.1016/0378-1119(89)90227-8. PMID 2673923.

[Costa-5] Costa ML, Escaleira R, Cataldo A, Oliveira F, Mermelstein CS. Desmin: molecular interactions and putative functions of the muscle intermediate filament protein. Braz. J. Med. Biol. Res.. 2004, s. 1819–30. DOI /S0100-879X2004001200007. PMID 15558188.

[Bar-6] Bär H, Strelkov SV, Sjöberg G, Aebi U, Herrmann H. The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation?. J. Struct. Biol.. 2004, s. 137–52. DOI 10.1016/j.jsb.2004.04.003. PMID 15477095.

[Li-7] Li Z, Mericskay M, Agbulut O, Butler-Browne G, Carlsson L, Thornell LE, Babinet C, Paulin D. Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J. Cell Biol.. 1997, s. 129–44. DOI 10.1083/jcb.139.1.129. PMID 9314534.

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