DLX5

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLX5 yw DLX5 a elwir hefyd yn Distal-less homeobox 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.3.

DLX5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DJN, 4RDU
Dynodwyr
Cyfenwau	DLX5, SHFM1D, AI385752, distal-less homeobox 5, SHFM1
Dynodwyr allanol	OMIM: 600028 HomoloGene: 3825 GeneCards: DLX5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • HMG box domain binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cydrannau o'r gell • cytoplasm • cnewyllyn cell Prosesau biolegol • skeletal system development • roof of mouth development • GO:0009373 regulation of transcription, DNA-templated • epithelial cell differentiation • axonogenesis • ossification • positive regulation of epithelial cell proliferation • positive regulation of canonical Wnt signaling pathway • anatomical structure formation involved in morphogenesis • bone morphogenesis • head development • cellular response to BMP stimulus • ear development • endochondral ossification • transcription by RNA polymerase II • BMP signaling pathway • olfactory pit development • transcription, DNA-templated • nervous system development • axon guidance • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • embryonic limb morphogenesis • inner ear morphogenesis • osteoblast differentiation • cell population proliferation • face morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • GO:1901313 positive regulation of gene expression • olfactory bulb interneuron differentiation • interneuron axon guidance • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1749	n/a
Ensembl	ENSG00000105880	n/a
UniProt	P56178	n/a
RefSeq (mRNA)	NM_005221	n/a
RefSeq (protein)	NP_005212	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLX5.

• SHFM1D

Llyfryddiaeth

• "Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker. ". Circulation. 2017. PMID 28904069.
• "Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. ". J Mol Biol. 2016. PMID 26829219.
• "Heterozygous DLX5 nonsense mutation associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated families. ". Birth Defects Res A Clin Mol Teratol. 2014. PMID 25196357.
• "Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation. ". Eur J Hum Genet. 2014. PMID 24496061.
• "Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation.". J Med Genet. 2012. PMID 22121204.