FGF8

FGF8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2FDB
Dynodwyr
Cyfenwau	FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8
Dynodwyr allanol	OMIM: 600483 HomoloGene: 7715 GeneCards: FGF8
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• type 1 fibroblast growth factor receptor binding; • type 2 fibroblast growth factor receptor binding; • growth factor activity; • fibroblast growth factor receptor binding; • chemoattractant activity; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cydrannau o'r gell	• extracellular region; • intracellular anatomical structure; • external side of plasma membrane; • extracellular space;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • cell migration involved in mesendoderm migration; • male genitalia development; • epithelial to mesenchymal transition involved in endocardial cushion formation; • outflow tract morphogenesis; • embryonic heart tube development; • mesonephros development; • heart looping; • forebrain neuron development; • blood vessel remodeling; • central nervous system neuron development; • positive regulation of ERK1 and ERK2 cascade; • metanephros development; • cell proliferation in forebrain; • positive regulation of mitotic nuclear division; • gonad development; • pharyngeal system development; • branching involved in salivary gland morphogenesis; • GO:0097285 apoptotic process; • dopaminergic neuron differentiation; • cell fate commitment; • limb morphogenesis; • kidney development; • lung development; • anatomical structure morphogenesis; • signal transduction involved in regulation of gene expression; • regulation of odontogenesis of dentin-containing tooth; • GO:0001306 response to oxidative stress; • embryo development ending in birth or egg hatching; • forebrain morphogenesis; • heart development; • telencephalon development; • branching involved in ureteric bud morphogenesis; • midbrain-hindbrain boundary development; • branching involved in blood vessel morphogenesis; • thyroid-stimulating hormone-secreting cell differentiation; • positive chemotaxis; • mesodermal cell migration; • cell differentiation; • dorsal/ventral axon guidance; • corticotropin hormone secreting cell differentiation; • organ induction; • neural plate morphogenesis; • positive regulation of organ growth; • negative regulation of apoptotic process; • BMP signaling pathway; • outflow tract septum morphogenesis; • odontogenesis; • thyroid gland development; • pallium development; • gastrulation; • canonical Wnt signaling pathway; • subpallium development; • lung morphogenesis; • GO:1904578 response to organic cyclic compound; • otic vesicle formation; • forebrain dorsal/ventral pattern formation; • heart morphogenesis; • aorta morphogenesis; • generation of neurons; • MAPK cascade; • neuroepithelial cell differentiation; • multicellular organism development; • fibroblast growth factor receptor signaling pathway; • GO:1901313 positive regulation of gene expression; • negative regulation of cardiac muscle tissue development; • determination of left/right symmetry; • inner ear morphogenesis; • positive regulation of cell population proliferation; • bone development; • motor neuron axon guidance; • positive regulation of cell division; • embryonic hindlimb morphogenesis; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • positive regulation of cell differentiation; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • positive regulation of G protein-coupled receptor signaling pathway; • positive regulation of peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	2253
	n/a
	ENSG00000107831
	n/a
	P55075
	n/a
	NM_001206389; NM_006119; NM_033163; NM_033164; NM_033165
	n/a
	NP_001193318; NP_006110; NP_149353; NP_149354; NP_149355
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF8 yw FGF8 a elwir hefyd yn Fibroblast growth factor 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF8.

HH6
AIGF
KAL6
FGF-8
HBGF-8

Llyfryddiaeth

"Fgf8 signaling for development of the midbrain and hindbrain. ". Dev Growth Differ. 2016. PMID 27273073.
"Heterozygous FGF8 mutations in patients presenting cryptorchidism and multiple VATER/VACTERL features without limb anomalies. ". Birth Defects Res A Clin Mol Teratol. 2014. PMID 25131394.
"Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer. ". Exp Cell Res. 2013. PMID 23466786.
"Fibroblast growth factor 8b causes progressive stromal and epithelial changes in the epididymis and degeneration of the seminiferous epithelium in the testis of transgenic mice. ". Biol Reprod. 2012. PMID 22423049.
"FGF8b oncogene mediates proliferation and invasion of Epstein-Barr virus-associated nasopharyngeal carcinoma cells: implication for viral-mediated FGF8b upregulation.". Oncogene. 2011. PMID 21119603.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FGF8 - Cronfa NCBI

[2]

[1]