NPM1

Protein sy'n cael ei godio yn y corff dynol gan y genyn NPM1 yw NPM1 a elwir hefyd yn Nucleophosmin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q35.1.

NPM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2LLH, 2P1B, 2VXD
Dynodwyr
Cyfenwau	NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1
Dynodwyr allanol	OMIM: 164040 HomoloGene: 81697 GeneCards: NPM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ribosomal large subunit binding • protein homodimerization activity • ribosomal small subunit binding • unfolded protein binding • GO:0001105 transcription coactivator activity • protein kinase inhibitor activity • GO:0031493 histone binding • Tat protein binding • NF-kappaB binding • GO:0001948, GO:0016582 protein binding • RNA binding • protein heterodimerization activity • nucleic acid binding • protein kinase binding • transcription factor binding • rRNA binding • protein N-terminus binding • chromatin binding Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • spindle pole centrosome • nucleoplasm • microtubule organizing center • nucleolus • Cytosgerbwd • cnewyllyn cell • protein-DNA complex • granular component • centrosome • cytosol • large ribosomal subunit • small ribosomal subunit • nuclear speck • GO:0009327 protein-containing complex • ribonucleoprotein complex Prosesau biolegol • centrosome cycle • regulation of eIF2 alpha phosphorylation by dsRNA • positive regulation of cell cycle G2/M phase transition • negative regulation of centrosome duplication • regulation of centriole replication • response to stress • positive regulation of translation • GO:0061641 CENP-A containing chromatin assembly • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of NF-kappaB transcription factor activity • protein complex oligomerization • negative regulation of protein kinase activity by regulation of protein phosphorylation • regulation of endodeoxyribonuclease activity • regulation of endoribonuclease activity • ribosome assembly • intracellular protein transport • GO:0100026 DNA repair • GO:0072468 signal transduction • negative regulation of cell population proliferation • nucleosome assembly • GO:0022415 viral process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to UV • ribosomal large subunit export from nucleus • ribosomal small subunit export from nucleus • rRNA export from nucleus • cell volume homeostasis • nucleocytoplasmic transport • GO:0034613 protein localization • positive regulation of cell population proliferation • posttranscriptional regulation of gene expression • negative regulation of gene expression • regulation of centrosome duplication • positive regulation of centrosome duplication • cell growth • positive regulation of cellular biosynthetic process • positive regulation of protein ubiquitination • regulation of protein stability • ribosomal large subunit biogenesis • ribosomal small subunit biogenesis • negative regulation of apoptotic process • regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of protein kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of mRNA splicing, via spliceosome • protein stabilization • protein homooligomerization • regulation of cell cycle • positive regulation of protein localization to nucleolus • chromatin remodeling • regulation of mRNA stability involved in cellular response to UV Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4869	n/a
Ensembl	ENSG00000181163	n/a
UniProt	P06748	n/a
RefSeq (mRNA)	NM_001037738 NM_002520 NM_199185 NM_001355006 NM_001355009 NM_001355007 NM_001355010	n/a
RefSeq (protein)	NP_001032827 NP_002511 NP_954654 NP_001341935 NP_001341938 NP_001341936 NP_001341939	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NPM1.

• B23
• NPM

Llyfryddiaeth

• "Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance. ". Am J Hematol. 2017. PMID 28707414.
• "Localization of AML-related nucleophosmin mutant depends on its subtype and is highly affected by its interaction with wild-type NPM. ". PLoS One. 2017. PMID 28384310.
• "Relocation of NPM Affects the Malignant Phenotypes of Hepatoma SMMC-7721 Cells. ". J Cell Biochem. 2017. PMID 28262969.
• "Coexisting and cooperating mutations in NPM1-mutated acute myeloid leukemia. ". Leuk Res. 2017. PMID 28152414.
• "Biological and clinical consequences of NPM1 mutations in AML.". Leukemia. 2017. PMID 28111462.