RXRA

Protein sy'n cael ei godio yn y corff dynol gan y genyn RXRA yw RXRA a elwir hefyd yn Retinoid X receptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.2.

RXRA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 5EC9, 4ZSH
Dynodwyr
Cyfenwau	RXRA, NR2B1, Retinoid X receptor alpha, RXR-alpha, RXRalpha
Dynodwyr allanol	OMIM: 180245 HomoloGene: 2220 GeneCards: RXRA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vitamin D response element binding • GO:0001105 transcription coactivator activity • transcription factor binding • retinoic acid-responsive element binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • chromatin DNA binding • vitamin D receptor binding • retinoic acid binding • double-stranded DNA binding • zinc ion binding • nuclear receptor binding • peptide binding • DNA binding domain binding • LBD domain binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signaling receptor activity Cydrannau o'r gell • receptor complex • nucleoplasm • RNA polymerase II transcription regulator complex • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • steroid hormone mediated signaling pathway • regulation of branching involved in prostate gland morphogenesis • GO:0009373 regulation of transcription, DNA-templated • placenta development • peroxisome proliferator activated receptor signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cholesterol metabolic process • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • cardiac muscle cell proliferation • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • ventricular cardiac muscle tissue morphogenesis • heart development • retinoic acid receptor signaling pathway • maternal placenta development • modulation by virus of host process • vitamin metabolic process • bile acid and bile salt transport • ventricular cardiac muscle cell differentiation • camera-type eye development • GO:0022415 viral process • protein homotetramerization • transcription initiation from RNA polymerase II promoter • embryo implantation • positive regulation of translational initiation by iron • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • response to retinoic acid • regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6256	n/a
Ensembl	ENSG00000186350	n/a
UniProt	P19793	n/a
RefSeq (mRNA)	NM_002957 NM_001291920 NM_001291921	n/a
RefSeq (protein)	NP_001278849 NP_001278850 NP_002948	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RXRA.

• NR2B1

Llyfryddiaeth

• "Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes. ". J Biol Chem. 2017. PMID 27852823.
• "Protective effects of retinoid x receptors on retina pigment epithelium cells. ". Biochim Biophys Acta. 2016. PMID 26883505.
• "Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling. ". PLoS Comput Biol. 2016. PMID 26727233.
• "Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis. ". Med Sci Monit. 2015. PMID 26610845.
• "Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.". Brain. 2015. PMID 26463675.