SERPINA5

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINA5 yw SERPINA5 a elwir hefyd yn Plasma serine protease inhibitor a Serpin family A member 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.13.

SERPINA5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DY0, 1LQ8, 2HI9, 2OL2
Dynodwyr
Cyfenwau	SERPINA5, PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI, serpin family A member 5
Dynodwyr allanol	OMIM: 601841 HomoloGene: 20159 GeneCards: SERPINA5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • retinoic acid binding • heparin binding • phosphatidylcholine binding • glycosaminoglycan binding • acrosin binding • protease binding • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • platelet alpha granule • protein C inhibitor-TMPRSS11E complex • platelet dense tubular network • protein C inhibitor-plasma kallikrein complex • bilen • protein C inhibitor-PLAU complex • protein C inhibitor-coagulation factor Xa complex • acrosomal membrane • protein C inhibitor-thrombin complex • protein C inhibitor-coagulation factor XI complex • extracellular region • protein C inhibitor-KLK3 complex • protein C inhibitor-coagulation factor V complex • protein C inhibitor-TMPRSS7 complex • protein C inhibitor-PLAT complex • extracellular exosome • external side of plasma membrane • extracellular space • GO:0009327 protein-containing complex • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of proteolysis • fusion of sperm to egg plasma membrane involved in single fertilization • negative regulation of peptidase activity • lipid transport • blood coagulation • negative regulation of hydrolase activity • single fertilization • spermatogenesis • negative regulation of endopeptidase activity • seminal vesicle development • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5104	n/a
Ensembl	ENSG00000188488	n/a
UniProt	P05154	n/a
RefSeq (mRNA)	NM_000624	n/a
RefSeq (protein)	NP_000615	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINA5.

• PCI
• PAI3
• PAI-3
• PCI-B
• PROCI
• PLANH3

Llyfryddiaeth

• "Identification of CpG Sites of SERPINA5Promoter with Opposite Methylation Patterns in Benign and Malignant Prostate Cells. ". Anticancer Res. 2017. PMID 29187436.
• "Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability. ". Thromb Res. 2015. PMID 25887633.
• "Increased Serpin A5 levels in the cervicovaginal fluid of HIV-1 exposed seronegatives suggest that a subtle balance between serine proteases and their inhibitors may determine susceptibility to HIV-1 infection. ". Virology. 2014. PMID 24928035.
• "A novel protein C inhibitor gene mutation in pediatric stroke patients after bone marrow transplantation. ". Mol Biol Rep. 2013. PMID 23670045.
• "Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer.". PLoS One. 2013. PMID 23520464.