SIRPA

SIRPA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JJS, 2JJT, 2UV3, 2WNG, 4CMM
Dynodwyr
Cyfenwau	SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, Signal-regulatory protein alpha, signal regulatory protein alpha
Dynodwyr allanol	OMIM: 602461 HomoloGene: 7246 GeneCards: SIRPA
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• SH3 domain binding; • protein phosphatase binding; • GO:0005083 GTPase regulator activity; • protein binding involved in heterotypic cell-cell adhesion; • cell-cell adhesion mediator activity; • protein antigen binding; • protein tyrosine kinase binding;
Cydrannau o'r gell	• integral component of membrane; • Cellbilen; • extracellular exosome; • bilen; • tertiary granule membrane; • ficolin-1-rich granule membrane; • integral component of plasma membrane; • cell surface;
Prosesau biolegol	• cell adhesion; • leukocyte migration; • neutrophil degranulation; • GO:0033128 negative regulation of protein phosphorylation; • regulation of gene expression; • cell migration; • positive regulation of cell-cell adhesion; • regulation of interferon-gamma production; • regulation of interleukin-1 beta production; • regulation of interleukin-6 production; • regulation of tumor necrosis factor production; • negative regulation of interferon-beta production; • negative regulation of interleukin-6 production; • negative regulation of tumor necrosis factor production; • heterotypic cell-cell adhesion; • monocyte extravasation; • negative regulation of nitric oxide biosynthetic process; • regulation of nitric oxide biosynthetic process; • negative regulation of JNK cascade; • negative regulation of inflammatory response; • negative regulation of phagocytosis; • positive regulation of phagocytosis; • GO:0048552 regulation of catalytic activity; • positive regulation of T cell activation; • cellular response to hydrogen peroxide; • negative regulation of ERK1 and ERK2 cascade; • cellular response to lipopolysaccharide; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to interleukin-12; • negative regulation of macrophage inflammatory protein 1 alpha production; • negative regulation of chemokine (C-C motif) ligand 5 production; • cell-cell adhesion; • negative regulation of cytokine production involved in inflammatory response; • negative regulation of I-kappaB phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	140885
	n/a
	ENSG00000198053
	n/a
	P78324
	n/a
	NM_001040022; NM_001040023; NM_080792; NM_001330728
	n/a
	NP_001035111; NP_001035112; NP_001317657; NP_542970
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIRPA yw SIRPA a elwir hefyd yn Signal regulatory protein alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIRPA.

BIT
MFR
P84
SIRP
MYD-1
SHPS1
CD172A
PTPNS1

Llyfryddiaeth

"Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation. ". J Innate Immun. 2014. PMID 24516072.
"Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state. ". Nat Commun. 2013. PMID 24026300.
"TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets. ". PLoS One. 2017. PMID 29084248.
"Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling. ". J Biol Chem. 2015. PMID 26534964.
"Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon.". Immunol Res. 2016. PMID 26492885.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SIRPA - Cronfa NCBI

[2]

[1]