SIRT2

SIRT2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1J8F, 3ZGO, 3ZGV, 4L3O, 4R8M, 4RMG, 4RMH, 4RMI, 4RMJ, 4Y6O, 5DY4, 5D7O, 5DY5, 4Y6L, 4Y6Q, 4X3O, 4X3P, 5D7P, 5D7Q, 5FYQ
Dynodwyr
Cyfenwau	SIRT2, SIR2, SIR2L, SIR2L2, sirtuin 2
Dynodwyr allanol	OMIM: 604480 HomoloGene: 40823 GeneCards: SIRT2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• histone deacetylase binding; • transcription factor binding; • metal ion binding; • protein deacetylase activity; • zinc ion binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase binding; • tubulin deacetylase activity; • NAD-dependent histone deacetylase activity (H4-K16 specific); • NAD-dependent protein deacetylase activity; • histone deacetylase activity; • ubiquitin binding; • NAD+ binding; • beta-tubulin binding; • NAD+ ADP-ribosyltransferase activity; • hydrolase activity; • NAD-dependent histone deacetylase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • microtubule organizing center; • chromatin silencing complex; • perinuclear region of cytoplasm; • paranode region of axon; • microtubule; • Cytosgerbwd; • cnewyllyn cell; • centrosome; • cell projection; • myelin sheath; • glial cell projection; • Schmidt-Lanterman incisure; • paranodal junction; • perikaryon; • growth cone; • spindle; • Cromosom; • lateral loop; • mitotic spindle; • meiotic spindle; • midbody; • centriole; • juxtaparanode region of axon; • telomere; • nucleolus; • mitocondria; • Cellbilen;
Prosesau biolegol	• cellular response to molecule of bacterial origin; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; • cellular response to epinephrine stimulus; • tubulin deacetylation; • rDNA heterochromatin assembly; • phosphatidylinositol 3-kinase signaling; • cell cycle; • positive regulation of DNA binding; • negative regulation of autophagy; • cellular response to hypoxia; • negative regulation of cell population proliferation; • proteasome-mediated ubiquitin-dependent protein catabolic process; • cellular lipid catabolic process; • histone H3 deacetylation; • peptidyl-lysine deacetylation; • negative regulation of fat cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • substantia nigra development; • GO:1903363 negative regulation of protein catabolic process; • negative regulation of NLRP3 inflammasome complex assembly; • negative regulation of oligodendrocyte progenitor proliferation; • regulation of fat cell differentiation; • transcription, DNA-templated; • myelination in peripheral nervous system; • histone H4 deacetylation; • regulation of myelination; • innate immune response; • hepatocyte growth factor receptor signaling pathway; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • regulation of exit from mitosis; • cell differentiation; • protein ADP-ribosylation; • immune system process; • cellular response to hepatocyte growth factor stimulus; • negative regulation of peptidyl-threonine phosphorylation; • regulation of phosphorylation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • nervous system development; • response to redox state; • protein deacetylation; • positive regulation of attachment of spindle microtubules to kinetochore; • GO:0007126 Meiosis; • cellular response to caloric restriction; • ripoptosome assembly involved in necroptotic process; • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of defense response to bacterium; • positive regulation of execution phase of apoptosis; • protein kinase B signaling; • negative regulation of striated muscle tissue development; • positive regulation of oocyte maturation; • regulation of cell cycle; • Cellraniad; • autophagy; • positive regulation of meiotic nuclear division; • cellular response to oxidative stress; • negative regulation of reactive oxygen species metabolic process; • histone deacetylation; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	22933
	n/a
	ENSG00000283100; ENSG00000068903
	n/a
	Q8IXJ6
	n/a
	NM_001193286; NM_012237; NM_030593
	n/a
	NP_001180215; NP_036369; NP_085096
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIRT2 yw SIRT2 a elwir hefyd yn Sirtuin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIRT2.

SIR2
SIR2L
SIR2L2

Llyfryddiaeth

"Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy. ". Cell Cycle. 2017. PMID 28166441.
"Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2. ". ACS Chem Biol. 2017. PMID 28103679.
"Sirtuin 2 mutations in human cancers impair its function in genome maintenance. ". J Biol Chem. 2017. PMID 28461331.
"Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction. ". PLoS One. 2017. PMID 28445509.
"Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.". Cell Rep. 2017. PMID 28273448.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SIRT2 - Cronfa NCBI

[2]

[1]