SMURF2

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMURF2 yw SMURF2 a elwir hefyd yn SMAD specific E3 ubiquitin protein ligase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q23.3-q24.1.

SMURF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZVD, 2DJY, 2JQZ, 2KXQ, 2LTZ
Dynodwyr
Cyfenwau	SMURF2, SMAD specific E3 ubiquitin protein ligase 2
Dynodwyr allanol	OMIM: 605532 HomoloGene: 41490 GeneCards: SMURF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transforming growth factor beta receptor binding • SMAD binding Cydrannau o'r gell • cytosol • bilen • ubiquitin ligase complex • Cellbilen • nucleoplasm • membrane raft • nuclear speck • cnewyllyn cell • cytoplasm Prosesau biolegol • positive regulation of canonical Wnt signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • positive regulation of trophoblast cell migration • ubiquitin-dependent SMAD protein catabolic process • regulation of transforming growth factor beta receptor signaling pathway • protein ubiquitination • GO:0045996 negative regulation of transcription, DNA-templated • protein polyubiquitination • Wnt signaling pathway, planar cell polarity pathway • protein deubiquitination • ubiquitin-dependent protein catabolic process • negative regulation of BMP signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • GO:1903364 positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	64750	n/a
Ensembl	ENSG00000108854	n/a
UniProt	Q9HAU4	n/a
RefSeq (mRNA)	NM_022739	n/a
RefSeq (protein)	NP_073576	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. ". Cancer Res. 2009. PMID 19155312.
• "Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, _target specificity, and functional implication. ". Am J Physiol Renal Physiol. 2008. PMID 18353873.
• "Ectopic expression of Smurf2 and acceleration of age-related intervertebral disc degeneration in a mouse model. ". J Neurosurg Spine. 2017. PMID 28387615.
• "Effect of SMURF2 _targeting on susceptibility to MEK inhibitors in melanoma. ". J Natl Cancer Inst. 2013. PMID 23250956.
• "Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy.". Neuropathol Appl Neurobiol. 2011. PMID 20819168.