UBQLN2

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBQLN2 yw UBQLN2 a elwir hefyd yn Ubiquilin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.21.

UBQLN2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J8C
Dynodwyr
Cyfenwau	UBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2
Dynodwyr allanol	OMIM: 300264 HomoloGene: 81830 GeneCards: UBQLN2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • polyubiquitin modification-dependent protein binding Cydrannau o'r gell • cytoplasm • autophagosome • Cellbilen • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • bilen • cytosol Prosesau biolegol • autophagy • regulation of autophagosome assembly • negative regulation of G protein-coupled receptor internalization • regulation of macroautophagy • ubiquitin-dependent ERAD pathway • negative regulation of clathrin-dependent endocytosis • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • autophagosome assembly • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	29978	n/a
Ensembl	ENSG00000188021	n/a
UniProt	Q9UHD9	n/a
RefSeq (mRNA)	NM_013444	n/a
RefSeq (protein)	NP_038472	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBQLN2.

• DSK2
• ALS15
• CHAP1
• N4BP4
• PLIC2
• HRIHFB2157

Llyfryddiaeth

• "Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2. ". Biochem Biophys Res Commun. 2016. PMID 26944018.
• "Ubiquilin2 as a novel marker for detection of urothelial carcinoma cells in urine. ". Diagn Cytopathol. 2016. PMID 26303000.
• "No Evidence for Pathogenic Role of UBQLN2 Mutations in Sporadic Amyotrophic Lateral Sclerosis in the Mainland Chinese Population. ". PLoS One. 2017. PMID 28125704.
• "Increased Ubqln2 expression causes neuron death in transgenic rats. ". J Neurochem. 2016. PMID 27456931.
• "[Ubiquilin-2 immunostaining - a new marker as a diagnostic supplement in urine cytology?].". Urologe A. 2016. PMID 27168037.