IGF-1

IGF-1 (Insulin-like Growth Factor-1) er et peptidhormon, hvis molekylære struktur ligner insulins. IGF-1 spiller en vigtig rolle i barndommens vækst og har anabolske effekter hos voksne. Når væksthormon udledes i blodet fra forlappen i hypofysen (adenohypofysen,) stimulerer det syntesen af IGF-1 i leveren.

IGF1
Tilgængelige strukturer PDB Ortologsøgning: PDBe RCSB Liste over PDB-idkoder 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Identifikatorer
Aliaser	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
External IDs	OMIM: 147440 HomoloGene: 515 GeneCards: IGF1
Genetisk-relaterede sygdomme
growth delay due to insulin-like growth factor type 1 deficiency
Genontologi Molekylær funktion • hormone activity • insulin receptor binding • growth factor activity • integrin binding • GO:0001948, GO:0016582 proteinbinding • insulin-like growth factor receptor binding Cellulær komponent • ekstracellulære region • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • cellemembran • ekstracellulære rum Biologisk proces • positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • DNA-replikation • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • cell population proliferation • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • genudtryksregulering • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • muscle hypertrophy • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • GO:0072468 Signaltransduktion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
RNA-udtryksmønster
Flere henvisninger til udtrykdata
Ortologer
Art	Menneske	Mus
Entrez	3479	24482
Ensembl	ENSG00000017427	ENSRNOG00000004517
UniProt	P05019	P08025
RefSeq (mRNA)	NM_000618 NM_001111283 NM_001111284 NM_001111285	NM_001082477 NM_001082478 NM_001082479 NM_178866
RefSeq (protein)	NP_000609 NP_001104753 NP_001104754 NP_001104755	NP_001075946 NP_001075947 NP_001075948 NP_849197
Location (UCSC)	n/a	Chr 7: 22.28 – 22.36 Mb
PubMed-søgning
Wikidata
Vis/Rediger Menneske Vis/Rediger Mus

IGF-1's rumlige opbygning. Helixstrukturer er angivet i rødt/gult, mens de grå rør er den del af polypeptidet som ikke har nogen veldefineret struktur (tilfældig kæde).

Produktion og cirkulation

IGF-1 består af 70 aminosyrer i en enkelt kæde med tre intramolekylære disulfidbroer. IGF-1 har en molekylvægt på 7649 dalton. IGF-1 produceres i leveren og andre endokrine væv. Produktionen er stimuleret af væksthormon og hæmmet af mangel på næringsstoffer. En stor del af det cirkulerende IGF-1 er fastgjort til IGF-bindende proteiner.

Næsten alle celler i den menneskelige krop berøres af IGF-1, specielt muskel-, brusk-, knogle-, lever-, nerve-, hud- og lungeceller. Udover insulin-lignende effekter, medvirker IGF-1 også til regulering af cellers vækst og udvikling, specielt i nerveceller, som også syntetiserer DNA.

IGF-1 produceres igennem hele livet. Den største mængde IGF-1 produceres i puberteten, mens den laveste produktion forekommer når man bliver gammel.