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Can We Trust the Transgenic Mouse? Insights from Computer Simulations

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Functional Imaging and Modeling of the Heart (FIMH 2007)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 4466))

Abstract

Over the past several decades, the mouse has gained prominence in the cardiac electrophysiology literature as the animal model of choice. Using computer models of the mouse and human ECG, this paper is a step toward understanding when the mouse succeeds and fails to mimic functional changes resulting from disease states and drug interactions.

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Authors and Affiliations

  1. Bucknell University, Lewisburg PA 17837, USA

    Joseph Tranquillo & Adhira Sunkara

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  1. Joseph Tranquillo
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  2. Adhira Sunkara
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Frank B. Sachse Gunnar Seemann

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© 2007 Springer Berlin Heidelberg

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Tranquillo, J., Sunkara, A. (2007). Can We Trust the Transgenic Mouse? Insights from Computer Simulations. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_22

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  • DOI: https://doi.org/10.1007/978-3-540-72907-5_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-72906-8

  • Online ISBN: 978-3-540-72907-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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