References
Courts C, Montesinos-Rongen M, Martin-Subero JI et al (2007) Transcriptional profiling of the nuclear factor-kappaB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression. J Neuropathol Exp Neurol 66:230–237
Deckert M, Engert A, Brück W et al. (2011) Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Leukemia: doi: 10.1038/leu.2011.1169
Deckert M, Paulus W (2007) Malignant Lymphomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumors pathology and genetics of tumours of the nervous system 4th edn. IRAC, Lyon, pp 188–192
Kluin P, Deckert M, Ferry JA (2008) Primary diffuse large B-cell lymphoma of the CNS. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon, pp 240–241
Montesinos-Rongen M, Schmitz R, Brunn A et al (2010) Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma. Acta Neuropathol 120:529–535
Montesinos-Rongen M, Siebert R, Deckert M (2009) Primary lymphoma of the central nervous system: just DLBCL or not? Blood 113:7–10
Ngo VN, Young RM, Schmitz R et al (2011) Oncogenically active MYD88 mutations in human lymphoma. Nature 470:115–119
Puente XS, Pinyol M, Quesada V et al (2011) Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101–105
Acknowledgments
The excellent technical assistance of Hatice Önder is appreciated. This work was supported by grants from the Deutsche Krebshilfe/Dr. Mildred Scheel-Stiftung für Krebsforschung (grant no.: 109471), the Deutsche Forschungsgemeinschaft (grant no.: De 485/9-1), and the Marga und Walter Boll-Stiftung (grant no.: 210-01-10).
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Montesinos-Rongen, M., Godlewska, E., Brunn, A. et al. Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma. Acta Neuropathol 122, 791–792 (2011). https://doi.org/10.1007/s00401-011-0891-2
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DOI: https://doi.org/10.1007/s00401-011-0891-2