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DNA repair gene variants in endometrial carcinoma

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Abstract

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. In this study, we investigated the association of the polymorphisms in the DNA repair genes, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys, with endometrium cancer risk. Two hundred and sixty-two women were included in the study. Endometrial biopsy was performed, and on the basis of diagnosis and histological examination, women were divided into two groups: a control group (n = 158) and an endometrial cancer group (n = 104). Genotypes were determined by PCR–RFLP assays in endometrial carcinoma patients and age-matched controls. In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls. Frequencies of Thr/Thr genotype in XRCC3 were increased in controls compared with patients and seem to be protected from endometrial cancer. Our findings suggest that XRCC1, XRCC3, XPD, XPG, APE1, and HOGG1 genetic variants may be associated with endometrial cancer in Turkish women.

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Acknowledgments

This research was supported in part by the TUBITAK grants: Project no: 109S018.

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Authors and Affiliations

  1. Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Vakif Gureba Cad. Capa, 34390, Istanbul, Turkey

    Zeynep Birsu Cincin & Bedia Cakmakoglu

  2. Department of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

    Ahmet Cem Iyibozkurt

  3. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

    Sibel Bulgurcuoglu Kuran

Authors
  1. Zeynep Birsu Cincin
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  3. Sibel Bulgurcuoglu Kuran
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  4. Bedia Cakmakoglu
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Correspondence to Bedia Cakmakoglu.

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Cincin, Z.B., Iyibozkurt, A.C., Kuran, S.B. et al. DNA repair gene variants in endometrial carcinoma. Med Oncol 29, 2949–2954 (2012). https://doi.org/10.1007/s12032-012-0162-7

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  • DOI: https://doi.org/10.1007/s12032-012-0162-7

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