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Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer

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Abstract

Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on _target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Only 31.4% (11 of 35) and 26.9% (7 of 26) of colon and rectal cancer cases respectively showed an increase in SHH expression in tumours compared to 72.7% (24 of 33) of the pancreatic cancer cases when compared with their adjacent normal tissues. Our results suggest that SHH may have a strong role in the predisposition of Pancreatic cancer and could possibly be used as a diagnostic or prognostic biomarker.

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Acknowledgements

The authors gratefully acknowledge the technical staff of the Department of General Surgery and Surgical Gastroenterology who helped us in procuring the tissue samples.

Funding

The Study was supported by Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir 190011 India (Grant no# No. SIMS/Acad/20 of 2015).

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India

    Madiha Niyaz, Mosin S. Khan & Syed Mudassar

  2. Department of General and Minimal Invasive Surgery, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, 190011, India

    Rauf A. Wani

  3. Department of Surgical Gastroenterology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, 190011, India

    Omar J. Shah

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  1. Madiha Niyaz
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Correspondence to Syed Mudassar.

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All the patients were informed about the study and tissue samples were obtained after taking written consent from patients.

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Niyaz, M., Khan, M.S., Wani, R.A. et al. Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer. Pathol. Oncol. Res. 26, 551–557 (2020). https://doi.org/10.1007/s12253-018-00564-2

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