Abstract
Scrapie is a slowly developing disease of the nervous system. Experiments on the effects of ultra-violet irradiation of suspensions of infected mouse brain extracts confirm that the agent responsible for it does not depend on a nucleic acid for its ability to replicate. No evidence is obtained, however, to indicate whether the agent is associated with a protein.
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References
Stamp, J. T., Brotherston, J. G., Zlotnik, I., MacKay, J. M. K., and Smith, W., J. Comp. Path., 69, 268 (1959).
Alper, T., Haig, D. A., and Clarke, M. C., Biochem. Biophys. Res. Commun., 22, 278 (1966).
Eklund, C. M., Kennedy, R. C., and Hadlow, W. J., J. Infect. Dis., 117, 15 (1967).
Haig, D. A., and Clarke, M. C., in Slow, Latent and Temperate Virus Infections, NINDB, Monograph No. 5 (edit. by Gajdnsek, D. C., Gibbs, C. J., and Alpers, M.) (Washington, 1965).
Pattison, I. H., and Jones, K. M., Vet. Rec., 80, 2 (1967).
Magnus, I. A., Porter, A. D., McCree, K. J., Moreland, J. D., and Wright, W. D., Brit. J. Dermatol., 71, 261 (1959).
Parker, C. A., Proc. Roy. Soc., A, 220, 104 (1953).
Sztumpf-Kulikowska, E., Shugar, D., and Boag, J. W., Photochem. Photobiol., 6, 41 (1967).
Kärber, G., Arch. Exp. Path. Pharmak., 162, 480 (1931).
Fluke, J. D., and Pollard, E. C., Science, 110, 274 (1949).
Kleczkowski, J., and Kleczkowski, A., Photochem. Photobiol., 4, 201 (1965).
Winkler, U., Photochem. Photobiol., 3, 37 (1964).
Setlow, J. K., and Duggan, D. E., Biochim. Biophys. Acta, 87, 664 (1964).
Patrick, M. H., and Rupert, C. S., Photochem. Photobiol., 6, 1 (1967).
Setlow, R. B., in Mammalian Cytogenetics and Related Problems in Radiobiology, 291 (Pergamon Press, London, 1964).
Setlow, R., and Doyle, B., Biochim. Biophys. Acta, 24, 27 (1957).
Pattison, I. H., J. Comp. Path., 75, 159 (1965).
Field, E. J., Brit. Med. J., ii, 546 (1966).
Hadlow, W. J., Lancet, ii, 289 (1959).
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ALPER, T., CRAMP, W., HAIG, D. et al. Does the Agent of Scrapie Replicate without Nucleic Acid ?. Nature 214, 764–766 (1967). https://doi.org/10.1038/214764a0
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DOI: https://doi.org/10.1038/214764a0
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