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Spermidine to the rescue for an aging heart

Nature Medicine volume 22, pages 1389–1390 (2016)Cite this article

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A recent study shows that spermidine has beneficial effects on health and lifespan in mice, and that these effects are the result of improved cardiovascular function. Similar effects of spermidine on humans are supported by epidemiological studies.

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Figure 1: The effects of spermidine on aging and cardiovascular health.

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References

  1. Eisenberg, T. et al. Nat. Med. 22, 1428–1438 (2016)

    Article  CAS  Google Scholar 

  2. Pegg, A.E. J. Biol. Chem. 291, 14904–14912 (2016).

    Article  CAS  Google Scholar 

  3. Eisenberg, T. et al. Nat. Cell Biol. 11, 1305–1314 (2009).

    Article  CAS  Google Scholar 

  4. Taneike, M. et al. Autophagy 6, 600–606 (2010).

    Article  CAS  Google Scholar 

  5. de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M.N. & Madeo, F. Cell 157, 1515–1526 (2014).

    Article  CAS  Google Scholar 

  6. López-Otín, C., Galluzzi, L., Freije, J.M., Madeo, F. & Kroemer, G. Cell 166, 802–821 (2016).

    Article  Google Scholar 

  7. Morselli, E. et al. J. Cell Biol. 192, 615–629 (2011).

    Article  CAS  Google Scholar 

  8. Diaz, M., Degens, H., Vanhees, L., Austin, C. & Azzawi, M. Exp. Gerontol. 85, 41–47 (2016).

    Article  CAS  Google Scholar 

  9. Minois, N. Gerontology 60, 319–326 (2014).

    Article  CAS  Google Scholar 

  10. Soda, K. et al. J. Nutr. Sci. Vitaminol. (Tokyo) 55, 361–366 (2009).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Rafael de Cabo is at the National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.,

    Rafael de Cabo

  2. Pácido Navas is at Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto Carlos III, Universidad Pablo de Olavide, Sevilla, Spain.,

    Pácido Navas

Authors
  1. Rafael de Cabo
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  2. Pácido Navas
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Correspondence to Rafael de Cabo.

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The authors declare no competing financial interests.

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de Cabo, R., Navas, P. Spermidine to the rescue for an aging heart. Nat Med 22, 1389–1390 (2016). https://doi.org/10.1038/nm.4243

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