Original Articles

Acinar Cell Carcinoma of the Pancreas

Clinical Analysis of 115 Patients From Pancreatic Cancer Registry of Japan Pancreas Society

Kitagami, Hidehiko MD, PhD*; Kondo, Satoshi MD, PhD*; Hirano, Satoshi MD, PhD*; Kawakami, Hiroshi MD, PhD†; Egawa, Shinichi MD, PhD‡§; Tanaka, Masao MD, PhD‡∥

Author Information

From the Departments of *Surgical Oncology and †Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo; ‡Japan Pancreas Society, Tokyo; §Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, Sendai; and ∥Department of Surgery and Oncology, Graduate School of Medicine Science, Kyushu University, Fukuoka, Japan.

Received for publication December 4, 2006; accepted February 14, 2007.

Reprints: Hidehiko Kitagami, MD, PhD, Department of Surgery, Kitami Red Cross Hospital, Kita 6, Higashi 2, Kitami City, Hokkaido 090-8666, Japan (e-mail: [email protected]).

Pancreas 35(1):p 42-46, July 2007. | DOI: 10.1097/mpa.0b013e31804bfbd3

Abstract

Objectives: 

Acinar cell carcinoma (ACC) of the pancreas is a rare tumor, and many aspects remain unclear because no large-scale clinical studies have been conducted.

Methods: 

The present study investigated the clinical characteristics, treatment, and therapeutic outcomes of 115 patients registered in the Pancreatic Cancer Registry of the Japan Pancreas Society, and therapeutic plans were reviewed.

Results: 

Although ACC has been associated with advanced stage and poor prognosis, this tumor was resectable in 76.5% of the patients, and the 5-year survival rate after resection was favorable, being 43.9%.

Conclusions: 

Confirming the diagnosis of ACC preoperatively is difficult, but this diagnosis should be kept in mind while planning surgery for ordinary pancreatic cancer. Once the diagnosis has been confirmed, a possibility of surgical resection should be pursued to achieve better prognosis. If ACC is unresectable or recurrent, chemotherapy is likely to prove useful. Multidisciplinary therapy centering on the role of surgery will need to be established.

© 2007 Lippincott Williams & Wilkins, Inc.

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