2010 Volume 58 Issue 7 Pages 971-975
A total of 36 compounds (1—36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (−)-5,4′-dihydroxy-7,8-[(3″,4″-cis-dihydroxy-3″,4″-dihydro)-2″,2″-dimethylpyrano]-flavone (1), (−)-5,4′-dihydroxy-7,8-[(3″-hydroxy-4″-one)-2″,2″-dimethylpyrano]-flavone (2), and (−)-5,4′-dihydroxy-7,8-[(cis-3″-hydroxy-4″-ethoxy-3″,4″-dihydro)-2″,2″-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1—20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (TI) of 143.65.
