Antonio Franco may refer to:
- Antonio Franco (blessed) (1585–1626), Roman Catholic Italian priest and prelate
- Antonio Franco (footballer, 1911–1996), Spanish football midfielder and manager
- Antonio Franco (diplomat) (born 1937), Vatican diplomat
- António de Sousa Franco (1942–2004), Portuguese economist and politician
- Antonio Franco (journalist) (1947–2021), Spanish journalist
- Antonio Franco (footballer, born 1991), Paraguayan football goalkeeper