Blood–brain barrier disruption

Blood–brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood–brain barrier.^[1]

Purpose

The blood–brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases,^[2]^[3] blood–brain barrier disruption is needed for the anti-cancer drugs to be infused into an artery that goes to the brain.^[1]

Effects

Studies have shown that blood–brain barrier disruption can cause diseases in the central nervous system.^[4]^[5]

References

^ ^a ^b "Definition of blood–brain barrier disruption". www.cancer.gov. 2011-02-02. Retrieved 2023-02-09.
^ Tomkins, O.; Shelef, I.; Kaizerman, I.; Eliushin, A.; Afawi, Z.; Misk, A.; Gidon, M.; Cohen, A.; Zumsteg, D.; Friedman, A. (2008-07-01). "Blood–brain barrier disruption in post-traumatic epilepsy". Journal of Neurology, Neurosurgery & Psychiatry. 79 (7): 774–777. doi:10.1136/jnnp.2007.126425. ISSN 0022-3050. PMID 17991703. S2CID 29504371.
^ "Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors". ClinicalTrials.gov. Retrieved 2024-08-06.
^ Segura-Collar, Berta; Mata-Martínez, Pablo; Hernández-Laín, Aurelio; Sánchez-Gómez, Pilar; Gargini, Ricardo (June 2022). "Blood–brain barrier Disruption: A Common Driver of Central Nervous System Diseases". The Neuroscientist. 28 (3): 222–237. doi:10.1177/1073858420985838. hdl:20.500.12105/11670. ISSN 1089-4098. PMID 33446074. S2CID 231611519.
^ Okada, Takeshi; Suzuki, Hidenori; Travis, Zachary D.; Zhang, John H. (2020). "The Stroke-Induced Blood–brain barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic _target". Current Neuropharmacology. 18 (12): 1187–1212. doi:10.2174/1570159X18666200528143301. PMC 7770643. PMID 32484111.

[:0-1] "Definition of blood–brain barrier disruption". www.cancer.gov. 2011-02-02. Retrieved 2023-02-09.

[2] Tomkins, O.; Shelef, I.; Kaizerman, I.; Eliushin, A.; Afawi, Z.; Misk, A.; Gidon, M.; Cohen, A.; Zumsteg, D.; Friedman, A. (2008-07-01). "Blood–brain barrier disruption in post-traumatic epilepsy". Journal of Neurology, Neurosurgery & Psychiatry. 79 (7): 774–777. doi:10.1136/jnnp.2007.126425. ISSN 0022-3050. PMID 17991703. S2CID 29504371.

[l428-3] "Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors". ClinicalTrials.gov. Retrieved 2024-08-06.

[4] Segura-Collar, Berta; Mata-Martínez, Pablo; Hernández-Laín, Aurelio; Sánchez-Gómez, Pilar; Gargini, Ricardo (June 2022). "Blood–brain barrier Disruption: A Common Driver of Central Nervous System Diseases". The Neuroscientist. 28 (3): 222–237. doi:10.1177/1073858420985838. hdl:20.500.12105/11670. ISSN 1089-4098. PMID 33446074. S2CID 231611519.

[5] Okada, Takeshi; Suzuki, Hidenori; Travis, Zachary D.; Zhang, John H. (2020). "The Stroke-Induced Blood–brain barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic _target". Current Neuropharmacology. 18 (12): 1187–1212. doi:10.2174/1570159X18666200528143301. PMC 7770643. PMID 32484111.

[1]

[2]

[3]

[4]

[5]