SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene .[ 5] [ 6] [ 7]
The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma . In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.[ 8]
Elotuzumab is an antibody that _targets this protein.
^ a b c GRCh38: Ensembl release 89: ENSG00000026751 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038179 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion" . The Biochemical Journal . 361 (Pt 3): 431–6. doi :10.1042/0264-6021:3610431 . PMC 1222324 . PMID 11802771 .
^ Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily". Immunogenetics . 52 (3–4): 302–7. doi :10.1007/s002510000274 . PMID 11220635 . S2CID 39567095 .
^ "Entrez Gene: SLAMF7 SLAM family member 7" .
^ Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B (Feb 2014). "Robust isolation of malignant plasma cells in multiple myeloma" . Blood . 123 (9): 1336–40. doi :10.1182/blood-2013-09-529800 . PMID 24385542 .
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