Cdc42 binding protein kinase beta

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene.

CDC42BPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QFV, 3TKU, 4UAK, 4UAL
Identifiers
Aliases	CDC42BPB, MRCKB, CDC42 binding protein kinase beta, CHOCNS
External IDs	OMIM: 614062; MGI: 2136459; HomoloGene: 55945; GeneCards: CDC42BPB; OMA:CDC42BPB - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.32 Start 102,932,380 bp End 103,057,549 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 F1|12 60.94 cM Start 111,259,410 bp End 111,344,152 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastric mucosa body of uterus right frontal lobe right hemisphere of cerebellum anterior pituitary left ovary prefrontal cortex ectocervix canal of the cervix Top expressed in zygote otic vesicle secondary oocyte genital tubercle primary visual cortex superior frontal gyrus yolk sac tail of embryo superior cervical ganglion dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein serine/threonine kinase activity ATP binding magnesium ion binding protein-containing complex binding protein binding Cellular component cytoplasm membrane cell-cell junction plasma membrane cell junction cell leading edge actomyosin cytoskeleton extracellular exosome lamellipodium cell projection Biological process intracellular signal transduction phosphorylation actomyosin structure organization establishment or maintenance of cell polarity protein phosphorylation cytoskeleton organization cell migration signal transduction actin cytoskeleton organization actin cytoskeleton reorganization peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9578 217866 Ensembl ENSG00000198752 ENSMUSG00000021279 UniProt Q9Y5S2 Q86XZ8 Q7TT50 RefSeq (mRNA) NM_006035 NM_183016 RefSeq (protein) NP_006026 NP_006026.3 NP_898837 Location (UCSC) Chr 14: 102.93 – 103.06 Mb Chr 12: 111.26 – 111.34 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rats suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.

Further reading

• Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM (2008). "Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta". J. Biol. Chem. 283 (16): 10543–9. doi:10.1074/jbc.M707463200. PMC 2447637. PMID 18263588.
• Kim YJ, Kim NY, Lee MK, Choi HJ, Baek HJ, Nam CH (2010). "Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients". Exp. Mol. Med. 42 (5): 319–26. doi:10.3858/emm.2010.42.5.030. PMC 2877252. PMID 20177145.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M (2011). "Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration". EMBO J. 30 (4): 665–78. doi:10.1038/emboj.2010.353. PMC 3041950. PMID 21240187.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.