Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.[2] Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.
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| Routes of administration | topical |
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| ECHA InfoCard | 100.048.870 |
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| Formula | C15H17ClN2O2 |
| Molar mass | 292.76 g·mol−1 |
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| Chirality | Racemic mixture |
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Indications and formulations
editIt is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.[citation needed]
Side effects
editIt may cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]
References
edit- ^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
- ^ a b Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.