Combs is a surname. Notable people with the surname include:
Sports:
- Beth Combs (born 1969), American basketball coach
- Chris Combs (defensive lineman) (born 1976), American football player
- Chris Combs (tight end) (born 1958), American football player
- Earle Combs (1899–1976), American center fielder and Baseball Hall of Fame member
- Frederick Combs (1935–1992), American actor
- Glen Combs (born 1946), American basketball player
- Jeremy Combs (born 1995), American basketball player for Israeli team Hapoel Ramat Gan Givatayim
- Merl Combs (1919–1981), a shortstop in Major League Baseball from 1947–1952
- Pat Combs (born 1966), a Philadelphia Phillies pitcher from 1989–1992
Television:
- Holly Marie Combs (born 1973), American actress
- Jeffrey Combs (born 1954), American character actor
- Ray Combs (1956–1996), American television game show host and stand-up comedian
Other:
- Allan Combs (born 1942), consciousness researcher and neuropsychologist
- Everett R. Combs (1876–1957), American politician from Virginia
- Jessi Combs (1983–2019), American race driver and actress
- Lewis Combs (1895–1996), United States Admiral
- Luke Combs (born 1990), American country music singer and songwriter
- Rodney Combs (born 1950), American NASCAR driver
- Sean Combs (born 1969), American record producer, CEO, clothing designer, actor, and rapper known as the Diddy Lama