DVL3

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.

DVL3
Identifiers
Aliases	DVL3, DRS3, dishevelled segment polarity protein 3
External IDs	OMIM: 601368; MGI: 108100; HomoloGene: 20928; GeneCards: DVL3; OMA:DVL3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.1 Start 184,155,377 bp End 184,173,614 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A3|16 12.46 cM Start 20,335,732 bp End 20,352,760 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence gastric mucosa muscle layer of sigmoid colon body of uterus apex of heart sural nerve right ovary left uterine tube left ovary Top expressed in cardiac muscle tissue of left ventricle external carotid artery internal carotid artery genital tubercle choroid plexus of fourth ventricle trigeminal ganglion tail of embryo molar ventricular zone zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding frizzled binding protease binding protein binding protein heterodimerization activity signaling receptor binding Cellular component cytoplasm cytosol Biological process positive regulation of protein phosphorylation intracellular signal transduction positive regulation of JUN kinase activity protein stabilization Wnt signaling pathway positive regulation of transcription, DNA-templated multicellular organism development positive regulation of GTPase activity negative regulation of canonical Wnt signaling pathway beta-catenin destruction complex disassembly non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway via JNK cascade canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway planar cell polarity pathway involved in neural tube closure positive regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1857 13544 Ensembl ENSG00000161202 ENSMUSG00000003233 UniProt Q92997 Q61062 RefSeq (mRNA) NM_004423 NM_007889 NM_001347176 RefSeq (protein) NP_004414 NP_001334105 NP_031915 Location (UCSC) Chr 3: 184.16 – 184.17 Mb Chr 16: 20.34 – 20.35 Mb PubMed search
Wikidata
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This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.

Interactions

DVL3 has been shown to interact with DAB2, DVL1 and PRPF3.

See also

• Dishevelled

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics. 42 (2): 302–310. doi:10.1006/geno.1997.4713. PMID 9192851.
• Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas". Biochem. Biophys. Res. Commun. 239 (2): 510–516. doi:10.1006/bbrc.1997.7500. PMID 9344861.
• Kishida S, Yamamoto H, Hino S, et al. (1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6): 4414–4422. doi:10.1128/mcb.19.6.4414. PMC 104400. PMID 10330181.
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–23797. doi:10.1074/jbc.M909107199. PMID 10806215.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–3094. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–52713. doi:10.1074/jbc.M408675200. PMID 15456783.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Chan DW, Chan CY, Yam JW, et al. (2006). "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer". Gastroenterology. 131 (4): 1218–1227. doi:10.1053/j.gastro.2006.07.020. PMID 17030191.