EIF3M

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

EIF3M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C, 5A5T
Identifiers
Aliases	EIF3M, B5, PCID1, TANGO7, hfl-B5, GA17, eukaryotic translation initiation factor 3 subunit M
External IDs	OMIM: 609641; MGI: 1351744; HomoloGene: 4639; GeneCards: EIF3M; OMA:EIF3M - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p13 Start 32,583,798 bp End 32,606,264 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E2|2 55.06 cM Start 104,830,001 bp End 104,847,425 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium superficial temporal artery parietal pleura body of pancreas ganglionic eminence left ovary oral cavity monocyte epithelium of nasopharynx endometrium Top expressed in epiblast ovary pancreas embryo ventricular zone ganglionic eminence embryo islet of Langerhans uterus spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor binding protein binding translation initiation factor activity Cellular component cytoplasm eukaryotic translation initiation factor 3 complex cytosol eukaryotic translation initiation factor 3 complex, eIF3m eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation cytoplasmic translational initiation protein biosynthesis formation of cytoplasmic translation initiation complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10480 98221 Ensembl ENSG00000149100 ENSMUSG00000027170 UniProt Q7L2H7 Q99JX4 RefSeq (mRNA) NM_001307929 NM_006360 NM_145380 RefSeq (protein) NP_001294858 NP_006351 NP_663355 Location (UCSC) Chr 11: 32.58 – 32.61 Mb Chr 2: 104.83 – 104.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV).

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Perez-Romero P, Fuller AO (2005). "The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection". J. Virol. 79 (12): 7431–7. doi:10.1128/JVI.79.12.7431-7437.2005. PMC 1143627. PMID 15919899.
• Perez A, Li QX, Perez-Romero P, et al. (2005). "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins". J. Virol. 79 (12): 7419–30. doi:10.1128/JVI.79.12.7419-7430.2005. PMC 1143644. PMID 15919898.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• Overview of all the structural information available in the PDB for UniProt: Q7L2H7 (Eukaryotic translation initiation factor 3 subunit M) at the PDBe-KB.