File:Interaction of MUC16-CA125 and mesothelin.tiff

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English: MUC16 (CA125) is heavily glycosylated with both O-linked and N-linked oligosaccharides. The peptide backbone of CA125 is composed of the N-terminal region, extensive Ser/Thr/Prorich tandem repeat (TR) containing 165 amino acids each with both N- and O-glycosylations, a SEA domain with high levels of O-glycosylation, and a C-terminal region with a short cytoplasmic tail. The N-glycan moiety of CA125 repeat units binds to the CA125-binding domain (named IAB), the helical structure around Tyr318 at the N-terminus of the cell surface mesothelin. Line, coil. Tube, helix.
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31 May 2020

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current22:47, 31 May 2020Thumbnail for version as of 22:47, 31 May 20201,500 × 1,211 (5.22 MB)BioshoreCross-wiki upload from en.wikipedia.org

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