Frank Uhlmann FRS[1] is a group leader at the Francis Crick Institute in London.[6][7][8][9][10][11][12]
Frank Uhlmann | |
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 Frank Uhlmann in 2015, portrait via the Royal Society | |
| Alma mater | University of Tübingen (PhD) |
| Awards |
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| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | Reconstitution and characterisation of human replication factor C (1997) |
| Website | crick |
Education
editUhlmann was educated at the University of Tübingen where he was awarded a PhD in 1997.[4][13] During his PhD, he worked with Jerard Hurwitz at the Memorial Sloan Kettering Cancer Center in New York City.[14][15][16]
Career
editFollowing his PhD, Uhlmann moved to the Research Institute of Molecular Pathology in Vienna for postdoctoral research with Kim Nasmyth. In 2000, he established a laboratory at the Imperial Cancer Research Fund (now Cancer Research UK)[17] in London, which ultimately became part of the Francis Crick Institute.[16]
Awards and honours
editUhlmann was elected a Fellow of the Royal Society (FRS) in 2015. His certificate of election reads:
Frank Uhlmann's discovery with Nasmyth of 'separase', the protease that cleaves the cohesive links between sister chromatids to trigger anaphase is a key contribution to our understanding of the cell cycle. He has made major contributions to our understanding of the mechanisms of sister chromatid cohesion, and their relationship to cell cycle regulation. He generated the first chromosome-wide high resolution maps of proteins involved in chromosome packaging and segregation. He showed that yeast cohesins accumulate at sites of converging transcription distinct from the sites where their loading factors bind, apparently reflecting interaction with the transcription apparatus; and that cohesin loading factors are recruited to specific chromosomal sites through interaction with the nucleosome remodelling complex Rsc. He has identified genes required for cohesion establishment, and shown that one of these, EcoI, acetylates cohesin during DNA replication, thereby locking it onto DNA and his studies of the link between cohesion regulation and the cell cycle have shown that as well as cleaving cohesin, separase promotes mitotic exit by activating the Cdc14 phosphatase in a protease-independent manner.[1]
In 2006, Uhlmann was also elected a member of the European Molecular Biology Organization (EMBO)[2] and awarded the EMBO Gold Medal.[5][3]
References
edit- ^ a b c "Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute". London: The Royal Society. Archived from the original on 2 May 2015.
- ^ a b "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 16 March 2015.
- ^ a b Uhlmann, F. (2007). "What is your assay for sister-chromatid cohesion?". The EMBO Journal. 26 (22): 4609–4618. doi:10.1038/sj.emboj.7601898. PMC 2080813. PMID 17962808.
- ^ a b "Frank Uhlmann: Mechanism and control of chromosome segregation". The Crick Institute. Archived from the original on 24 May 2015.
- ^ a b "Frank Uhlmann of London Research Institute wins 'EMBO Gold'". EMBO. Archived from the original on 14 April 2015.
- ^ Frank Uhlmann's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Uhlmann, F; Lottspeich, F; Nasmyth, K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature. 400 (6739): 37–42. Bibcode:1999Natur.400...37U. doi:10.1038/21831. PMID 10403247. S2CID 4354549.
- ^ Uhlmann, F; Wernic, D; Poupart, M. A.; Koonin, E. V.; Nasmyth, K (2000). "Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast". Cell. 103 (3): 375–86. doi:10.1016/s0092-8674(00)00130-6. PMID 11081625. S2CID 2667617.
- ^ Tóth, A; Ciosk, R; Uhlmann, F; Galova, M; Schleiffer, A; Nasmyth, K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes & Development. 13 (3): 320–33. doi:10.1101/gad.13.3.320. PMC 316435. PMID 9990856.
- ^ Nasmyth, K; Peters, J. M.; Uhlmann, F (2000). "Splitting the chromosome: Cutting the ties that bind sister chromatids". Science. 288 (5470). New York, N.Y.: 1379–85. Bibcode:2000Sci...288.1379N. doi:10.1126/science.288.5470.1379. PMID 10827941.
- ^ Godfrey, M; Kuilman, T; Uhlmann, F (2015). "Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast". PLOS Genetics. 11 (1): e1004907. doi:10.1371/journal.pgen.1004907. PMC 4287440. PMID 25569132.
- ^ Cheng, T. M.; Heeger, S; Chaleil, R. A.; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, P. A.; Uhlmann, F (2015). "A simple biophysical model emulates budding yeast chromosome condensation". eLife. 4: e05565. doi:10.7554/eLife.05565. PMC 4413874. PMID 25922992.
- ^ Uhlmann, Frank (1997). Reconstitution and characterization of human replication factor C (PhD thesis). University of Tübingen. OCLC 51443586.
- ^ Uhlmann, F; Gibbs, E; Cai, J; O'Donnell, M; Hurwitz, J (1997). "Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication". The Journal of Biological Chemistry. 272 (15): 10065–71. doi:10.1074/jbc.272.15.10065. PMID 9092550.
- ^ Uhlmann, F; Cai, J; Flores-Rozas, H; Dean, F. B.; Finkelstein, J; O'Donnell, M; Hurwitz, J (1996). "In vitro reconstitution of human replication factor C from its five subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6521–6. Bibcode:1996PNAS...93.6521U. doi:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
- ^ a b "Frank Uhlmann biography". London: Francis Crick Institute. Archived from the original on 25 May 2015.
- ^ "Frank Uhlmann: Understanding how cells divide". Cancer Research UK. 30 November 2010. Archived from the original on 27 May 2015.