GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]
The GVD regimen consists of three drugs, from which its name is derived:
- Gemcitabine;
- Vinorelbine; and
- Doxil, a pegylated liposomal formulation of doxorubicin.
Dosing
edit| Drug | Dose in transplant-naive patients | Dose in post-transplant patients | Mode | Days | |
|---|---|---|---|---|---|
| Gemcitabine | 1000 mg/m2 | 800 mg/m2 | IV infusion | Days 1, 8 | |
| Vinorelbine | 20 mg/m2 | 15 mg/m2 | IV bolus | Days 1, 8 | |
| Doxil | 15 mg/m2 | 10 mg/m2 | IV infusion | Days 1, 8 |
Repeated every 21 days (3 weeks).