Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).[5]

H2AB2
Identifiers
AliasesH2AB2, H2A.Bbd, H2A histone family member B2, H2A.B variant histone 2, H2AFB2, H2AB3, H2A.B.1
External IDsMGI: 3644875; HomoloGene: 129517; GeneCards: H2AB2; OMA:H2AB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017991

NM_001281531

RefSeq (protein)

NP_001017991

NP_001268460

Location (UCSC)Chr X: 155.38 – 155.38 MbChr X: 119.22 – 119.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277858Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000083616Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: H2A histone family".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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