HLA-DR2

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles^[1]
DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
15:01	76	23		6428
15:02	77	16		676
15:03	81	13		286
15:04	>50			1
15:05	>25			2
15:07	>50			1
				.
	DR16	DR2	DR15	N
16:01	41	29	19	703
16:02	47	30	16	239
16:04	>50			1

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,^[2] narcolepsy, tuberculoid leprosy^[3] (multi-drug-resistant tuberculosis or leprosy),^[4] ulcerative colitis (Japanese),^[5] primary biliary cirrhosis and autoimmune hepatitis.^[6] DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.^[7]

Genetic linkage

DR2 is linked to the HLA-DR51.

References

^ derived from IMGT/HLA
^ Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
^ van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.
^ Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 (Suppl 1): 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
^ Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.
^ Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.
^ Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.

[1] rived from IMGT/HLA

[2] Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.

[3] van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.

[pmid17445206-4] Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 (Suppl 1): 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.

[5] Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.

[6] Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.

[pmid17393393-7] Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.

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