The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.[8]
In February 2008, researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists, and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss.[9][11]
In 2013, it was found that mutations in LPAR6 give rise to the Cornish Rex cat breed, which has a form of ectodermal dysplasia characterised by short woolly hair which is susceptible to loss.[12]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (June 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492 (1): 127–138. doi:10.1016/S0167-4781(00)00094-4. PMID11004484.
^Ralevic V, Burnstock G (September 1998). "Receptors for purines and pyrimidines". Pharmacological Reviews. 50 (3): 413–492. PMID9755289.
^ abPasternack SM, von Kügelgen I, Al Aboud K, Lee YA, Rüschendorf F, Voss K, et al. (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nature Genetics. 40 (3): 329–334. doi:10.1038/ng.84. PMID18297070. S2CID20241237.
^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID20055701.
Toguchida J, McGee TL, Paterson JC, Eagle JR, Tucker S, Yandell DW, et al. (September 1993). "Complete genomic sequence of the human retinoblastoma susceptibility gene". Genomics. 17 (3): 535–543. doi:10.1006/geno.1993.1368. PMID7902321.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Li Q, Schachter JB, Harden TK, Nicholas RA (July 1997). "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses". Biochemical and Biophysical Research Communications. 236 (2): 455–460. doi:10.1006/bbrc.1997.6984. PMID9240460.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Ihara H, Hirukawa K, Goto S, Togari A (January 2005). "ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts". Biochemical and Biophysical Research Communications. 326 (2): 329–334. doi:10.1016/j.bbrc.2004.11.037. PMID15582581.
