Mitochondrial ribosomal protein L20

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.

MRPL20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDs	OMIM: 611833; MGI: 2137221; HomoloGene: 9941; GeneCards: MRPL20; OMA:MRPL20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 1,401,909 bp End 1,407,293 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 87.44 cM Start 155,887,335 bp End 155,894,432 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of nasopharynx germinal epithelium gingival epithelium Skeletal muscle tissue of rectus abdominis muscle of thigh amniotic fluid corpus epididymis mucosa of paranasal sinus Skeletal muscle tissue of biceps brachii Top expressed in gastrula right kidney embryo embryo spermatocyte spermatid morula epiblast submandibular gland neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding protein binding RNA binding structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis ribosomal large subunit assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55052 66448 Ensembl ENSG00000242485 ENSMUSG00000029066 UniProt Q9BYC9 Q9CQL4 RefSeq (mRNA) NM_017971 NM_001318485 NM_025570 RefSeq (protein) NP_001305414 NP_060441 NP_079846 Location (UCSC) Chr 1: 1.4 – 1.41 Mb Chr 4: 155.89 – 155.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.

Further reading

• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.