MRPL55

39S ribosomal protein L55, mitochondrial is a protein that in humans is encoded by the MRPL55 gene.

MRPL55
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPL55, AAVG5835, L55nt, MRP-L55, PRO19675, mitochondrial ribosomal protein L55
External IDs	OMIM: 611859; MGI: 1914462; HomoloGene: 12098; GeneCards: MRPL55; OMA:MRPL55 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.13 Start 228,106,679 bp End 228,109,312 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B1.3 Start 59,093,312 bp End 59,096,960 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart prefrontal cortex right lobe of liver Brodmann area 9 anterior cingulate cortex olfactory zone of nasal mucosa muscle of thigh anterior pituitary right adrenal gland left adrenal cortex Top expressed in right ventricle digastric muscle right kidney temporal muscle sternocleidomastoid muscle yolk sac myocardium of ventricle blastocyst morula cardiac muscle tissue of left ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component ribosome mitochondrion mitochondrial inner membrane mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation protein biosynthesis mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128308 67212 Ensembl ENSG00000162910 ENSMUSG00000036860 UniProt Q7Z7F7 Q9CZ83 RefSeq (mRNA) NM_181441 NM_181454 NM_181455 NM_181456 NM_181462 NM_181463 NM_181464 NM_181465 NM_001321284 NM_001302334 NM_001302335 NM_001302336 NM_026035 NM_001362908 NM_001362909 RefSeq (protein) NP_001308213 NP_852106 NP_852119 NP_852120 NP_852121 NP_852127 NP_852128 NP_852129 NP_852130 NP_001289263 NP_001289264 NP_001289265 NP_080311 NP_001349837 NP_001349838 Location (UCSC) Chr 1: 228.11 – 228.11 Mb Chr 11: 59.09 – 59.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–43969. doi:10.1074/jbc.M106510200. PMID 11551941.
• O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–79. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–480. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.