MYCBP2

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.

MYCBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GBW, 3HWJ
Identifiers
Aliases	MYCBP2, PAM, Myc-bp2, Phr, MYC binding protein 2, E3 ubiquitin protein ligase, PHR1, MYC binding protein 2
External IDs	OMIM: 610392; MGI: 2179432; HomoloGene: 9005; GeneCards: MYCBP2; OMA:MYCBP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q22.3 Start 77,042,474 bp End 77,327,094 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 E2.3|14 51.79 cM Start 103,350,847 bp End 103,584,250 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus hair follicle lateral nuclear group of thalamus Brodmann area 10 frontal pole cerebellar vermis nipple Pons pars compacta Top expressed in ventromedial nucleus anterior amygdaloid area medial geniculate nucleus lateral hypothalamus lateral septal nucleus paraventricular nucleus of hypothalamus mammillary body lateral geniculate nucleus ventral tegmental area medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding transferase activity guanyl-nucleotide exchange factor activity zinc ion binding protein homodimerization activity ubiquitin protein ligase activity Cellular component membrane nucleus cytoplasm cytoskeleton microtubule cytoskeleton axon cell projection intracellular membrane-bounded organelle Biological process regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated motor neuron axon guidance branchiomotor neuron axon guidance central nervous system projection neuron axonogenesis regulation of protein localization negative regulation of protein catabolic process cell morphogenesis involved in neuron differentiation neuromuscular process regulation of cytoskeleton organization regulation of axon guidance positive regulation of protein ubiquitination circadian regulation of gene expression rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23077 105689 Ensembl ENSG00000005810 ENSMUSG00000033004 UniProt O75592 Q7TPH6 RefSeq (mRNA) NM_015057 NM_207215 RefSeq (protein) NP_055872 NP_997098 Location (UCSC) Chr 13: 77.04 – 77.33 Mb Chr 14: 103.35 – 103.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Structure

PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains.

Interactions

MYCBP2 has been shown to interact with Myc.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V (2004). "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex". J. Biol. Chem. 279 (2): 1351–8. doi:10.1074/jbc.M310208200. PMID 14559897.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Pierre SC, Häusler J, Birod K, Geisslinger G, Scholich K (2004). "PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate". EMBO J. 23 (15): 3031–40. doi:10.1038/sj.emboj.7600321. PMC 514936. PMID 15257286.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gao X, Patel TB (2005). "Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity". Mol. Pharmacol. 67 (1): 42–9. doi:10.1124/mol.104.005355. PMID 15470080. S2CID 6049319.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "_targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.