Manuel Elkin Patarroyo Murillo (born November 3, 1946)[1] is a Colombian Professor of Pathology and Immunology who made the world's first attempt to create a synthetic vaccine against the protozoal parasite Plasmodium falciparum, the cause of severe malaria,[2] and responsible for the death of ~1.5 million people per year in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.
Manuel Elkin Patarroyo | |
|---|---|
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| Born | Manuel Elkin Patarroyo Murillo November 3, 1946 |
| Education | National University of Colombia (MD) |
| Known for | SPf66 Malaria vaccine |
| Medical career | |
| Profession | Physician-scientist |
| Institutions | |
| Sub-specialties | Pathologist |
| Research | Immunology |
| Awards |
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The vaccine candidate, first developed in 1987 in Colombia, was evaluated in clinical trials carried out by the WHO in Gambia, Tanzania and Thailand, and had mixed results.[3] In 2009, a comprehensive Cochrane review assessed the SPf66 as being not efficacious in Africa and Asia, and as having a low but statistically significant efficacy of 28% in South America.[4] Researchers and vaccine developers have been working on many approaches to bring forward the availability of a malaria vaccine."[5] More research and clinical trials are required for a universal vaccine to be implemented.
Patarroyo is a recipient of the TWAS Prize (1998).[6]
Scientific work
editPatarroyo started experimenting with animals since the 1980s, paying for wild monkeys captured in the Amazonian rainforest generating illegal traffic carried on by indigenous people who hunt the elusive monkeys for sale.[7]
The Corporation for the Sustainable Development of the South of the Amazon (Corpoamazonía), has opened a file (number 000102) for complaints about irregularities committed by the FIDIC (Fundación Instituto de Inmunología de Colombia) research team led by Manuel Elkin Patarroyo. The Ministry of Environment, Housing and Territorial Development of Colombia carried out an investigation motivated by the Corpoamazonía denunciations, in which there were evidenced within the facilities of the FIDIC 627 monkeys of the species Aotus nancymaae [Night_monkey], which had only been registered in Brazil and Peru and not in Colombian territory.[8] The export of these animals was not registered in the permits of the administrative authorities. For 2008, the alleged illegal trade in this animal species is under investigation by the Colombian government against the FIDIC. On 2012 the Administrative Court of Cundinamarca in Colombia revoked the permits of experimenting with 4,000 night monkeys (Aotus trivirgatus) for Patarroyo's jungle laboratory[9] but in March 2015 the decision was reversed and the experiments with primates were allowed to continue.
In April 2016, Dr. Patarroyo was awarded the honorary doctorate from the Ricardo Palma University, in whose official ceremony there was a controversy against defenders of the biodiversity of Peruvian wildlife. Dr. Patarroyo, using in its clinical trials species of green-tailed monkeys Aotus nancymaae, using more than 4000 specimens, which returned to its wild state without spleen, deprived of immune system,[10] reason why it was recriminated in the mentioned act . The ecologists supported their accusations based on allegations in SERFOR of Peru, for which the investigator had no response.
In November 2016 a Colombian journalistic investigation reveals the traffic and the environmental impact of Patarroyo's investigation[11]
References
edit- ^ Fundación Príncipe de Asturias. Manuel Elkin Patarroyo Archived 2008-05-13 at the Wayback Machine (Spanish). Premiados, Investigación Científica y Técnica, 1994.
- ^ Holloway, M. (1996) Profile: Manuel Elkin Patarroyo – The Man Who Would Conquer Malaria, Scientific American 275(6), 52-56.
- ^ - Susan Aldridge, Magic Molecules: How Drugs Work (Cambridge University Press, 1998), p. 89
- ^ - Graves, P. M. and Gelband, H. (2009) Vaccines for preventing malaria (SPf66) (Review), The Cochrane Library 2009, (2), pp.1-38. Archived 2011-07-20 at the Wayback Machine
- ^ - WHO (2010) Tables of Malaria Vaccine Projects Globally (Updated December 2010), Initiative for Vaccine Research.
- ^ "Prizes and Awards". The World Academy of Sciences. 2016.
- ^ Environmental Crime in Latin America: The Theft of Nature and the Poisoning on the land
- ^ Primate Rights vs Research: Battle in Colombian Rainforest
- ^ A legal victory for night monkeys. International Primate Protection League
- ^ Controversy Still Surrounds Malaria Vaccine
- ^ Hunting of the nocturnal monkey for scientific purposes threatens the species and devastates the environment(Spanish)
External links
edit- Structural and Immunological Principles Leading to Chemically Synthesized, Multiantigeni c, Multistage, Minimal Subunit-Based Vaccine Development Chemical Reviews doi:10.1021/cr100223m
- Emerging Rules for Subunit-Based, Multiantigenic, Multistage Chemically Synthesized Vaccines Accounts of Chemical Research doi:10.1021/ar700120t
- Toward A New Generation Of Vaccines For Malaria And Other Diseases in 'Science Daily'.
- Race for Malaria Money
- Scientists Herald Malaria Breakthrough
- Guardian Unlimited: Scientist whose dream of beating disease came true
- Tables of Malaria Vaccine Projects