Megasphaera

Megasphaera
Scientific classification
Domain:	Bacteria
Phylum:	Bacillota
Class:	Negativicutes
Order:	Veillonellales
Family:	Veillonellaceae
Genus:	Megasphaera; Rogosa 1971
Type species
	Megasphaera elsdenii; (Gutierrez et al. 1959) Rogosa 1971
Species
	See text

Megasphaera is a genus of Bacillota bacteria classified within the class Negativicutes.^[1]^[2]

This classification has been reexamined.^[3] It appears that this genus is a member of the Clostridia.

Phylogeny

16S rRNA based LTP_08_2023^[4]^[5]^[6]

120 marker proteins based GTDB 08-RS214^[7]^[8]^[9]

Megasphaera

M. micronuciformis Marchandin et al. 2003

	M. hutchinsoni Srinivasan et al. 2021

	M. lornae Srinivasan et al. 2021

M. massiliensis Padmanabhan et al. 2016

	M. elsdenii (Gutierrez et al. 1959) Rogosa 1971

	M. indica Lanjekar et al. 2014

	M. paucivorans Juvonen and Suihko 2006

	M. sueciensis Juvonen and Suihko 2006

	M. cerevisiae Engelmann and Weiss 1986

	M. vaginalis Srinivasan et al. 2021 non Bordigoni et al. 2020

Anaeroglobus geminatus Carlier et al. 2002

Megasphaera paucivorans

Anaeroglobus

Megasphaera vaginalis

"Colibacter massiliensis" Mailhe et al. 2017

	Megasphaera micronuciformis

	Anaeroglobus geminatus

"Caecibacter"

	"Megasphaera hominis"

	"Caecibacter massiliensis" Ricaboni et al. 2017 (incl. Megasphaera hexanoica)

Megasphaera

Unassigned species:

^ ^a ^b J.P. Euzéby. "Megasphaera". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2022-09-09.
^ ^a ^b Sayers; et al. "Megasphaera". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2022-09-09.
^ Yutin N, Galperin MY (2013) A genomic update on Clostridial phylogeny: Gram-negative spore formers and other misplaced Clostridia. Environ Microbiol doi: 10.1111/1462-2920.12173
^ "The LTP". Retrieved 20 November 2023.
^ "LTP_all tree in newick format". Retrieved 20 November 2023.
^ "LTP_08_2023 Release Notes" (PDF). Retrieved 20 November 2023.
^ "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 20 June 2023.
^ "bac120_r214.sp_labels". Genome Taxonomy Database. Retrieved 20 June 2023.
^ "Taxon History". Genome Taxonomy Database. Retrieved 20 June 2023.

Arik, H. D., Gulsen, N., Hayirli, A., & Alatas, M. S. (2019). Efficacy of Megasphaera elsdenii inoculation in subacute ruminal acidosis in cattle. Journal of animal physiology and animal nutrition, 103(2), 416–426.

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