Mycobacterium avium complex is a group of mycobacteria comprising Mycobacterium intracellulare and Mycobacterium avium that are commonly grouped because they infect humans together; this group, in turn, is part of the group of nontuberculous mycobacteria. These bacteria cause Mycobacterium avium-intracellulare infections or Mycobacterium avium complex infections in humans.[2] These bacteria are common and are found in fresh and salt water, in household dust and in soil.[3] MAC bacteria usually cause infection in those who are immunocompromised or those with severe lung disease.
| Mycobacterium avium complex | |
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| Species complex: | Mycobacterium avium complex
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| Binomial name | |
| Mycobacterium intracellulare Runyon 1965,[1] ATCC 13950
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| Mycobacterium avium Chester 1901 emend. Thorel et al. 1990
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Description
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- Negative control
- M. tuberculosis: Dry-appearing colonies
- Mycobacterium avium complex: Wet-appearing colonies
- M. gordonae: Yellowish colonies
In the Runyon classification, both bacteria are nonchromogens. They can be differentiated from M. tuberculosis and each other by commercially available DNA probes.[4]: 245
They are characterized as Gram-positive, nonmotile, acid-fast, short to long rods.[citation needed]
Colony characteristics
- Usually, colonies are smooth, rarely rough, and not pigmented colonies. Older colonies may become yellow.
Physiology
- Growth on Löwenstein-Jensen medium and Middlebrook 7H10 agar occurs at 37°C after seven or more days.
- The complex can be (but is not often) resistant to isoniazid, ethambutol, rifampin, and streptomycin.[5]
Differential characteristics
- M. intracellulare and M. avium form the M. avium complex (MAC).
- Remarkable ITS heterogeneity is seen within different M. intracellulare isolates.
Species
editType strains
editHuman health
editMAC bacteria enter most people's body when inhaled into the lungs or swallowed, but only cause infection in those who are immunocompromised or who have severe lung disease such as those with cystic fibrosis or chronic obstructive lung disease (COPD).[3] MAC infection can cause COPD and lymphadenitis, and can cause disseminated disease, especially in people with immunodeficiency.[4]: 245 During the last decade Mycobacterium chimaera (see below) infections following cardiothoracic surgery, especially open-heart surgery, have been increasingly reported worldwide.[8] Infections usually involve the respiratory system. Mycobacterium chimaera is acquired during cardiopulmonary bypass via bioaerosols emitted from contaminated heater-cooler units water systems. Due to nonspecific symptoms and long latency, postoperative Mycobacterium chimaera infections may not be promptly diagnosed and treated, and may become life-threatening.
History
editIn 2004, Tortoli et al. proposed the name M. chimaera for strains that a reverse hybridization–based line probe assay suggested belonged to MAIS (M. avium–M. intracellulare–M. scrofulaceum group), but were different from M. avium, M. intracellulare, or M. scrofulaceum. The new species name comes from the Chimera, a mythological being made up of parts of three different animals.[9][10]
References
edit- ^ Runyon, E. 1965. Pathogenic mycobacteria. Advances in Tuberculosis Research, 14, 235-287.
- ^ "Mycobacterium Avium Complex. MAI; MAC Information". Patient Info. 29 August 2014.
- ^ a b "Mycobacterium Avium Complex infections | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2020-03-29.
- ^ a b Jones-Lopez, Edward C.; Ellner, Jerrold J. (2011). "Chapter 35: Tuberculosis and Atypical Mycobacterial Infections". In Guerrant, Richard L.; Walker, David H.; Weller, Peter F. (eds.). Tropical infectious diseases : principles, pathogens, & practice (3rd ed.). Edinburgh: Saunders. ISBN 9780702039355.
- ^ Haworth CS, Banks J, Capstick T, Fisher AJ, Gorsuch T, Laurenson IF, Leitch A, Loebinger MR, Milburn HJ, Nightingale M, Ormerod P, Shingadia D, Smith D, Whitehead N, Wilson R, Floto RA (November 2017). "British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)". Thorax. 72 (Suppl 2): ii1–ii64. doi:10.1136/thoraxjnl-2017-210927. PMID 29054853.
- ^ Type strain of Mycobacterium intracellulare at BacDive - the Bacterial Diversity Metadatabase
- ^ Type strain of Mycobacterium avium at BacDive - the Bacterial Diversity Metadatabase
- ^ Riccardi, Niccolò; Monticelli, Jacopo; Antonello, Roberta Maria; Luzzati, Roberto; Gabrielli, Marco; Ferrarese, Maurizio; Codecasa, Luigi; Di Bella, Stefano; Giacobbe, Daniele Roberto (2020). "Mycobacterium chimaera infections: An update". Journal of Infection and Chemotherapy. 26 (3): 199–205. doi:10.1016/j.jiac.2019.11.004. PMID 31843377.
- ^ Henry, Ronnie (March 2017). "Etymologia: Mycobacterium chimaera". Emerg Infect Dis. 23 (3): 499. doi:10.3201/eid2303.ET2303. PMC 5382748.
Citing public domain text from the CDC.
- ^ Tortoli, E; Rindi, L; Garcia, MJ; Chiaradonna, P; Dei, R; Garzelli, C; Kroppenstedt, RM; Lari, N; Mattei, R; Mariottini, A; Mazzarelli, G; Murcia, MI; Nanetti, A; Piccoli, P; Scarparo, C (July 2004). "Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov". International Journal of Systematic and Evolutionary Microbiology. 54 (Pt 4): 1277–85. doi:10.1099/ijs.0.02777-0. PMID 15280303.
External links
edit- Mycobacterium avium Complex at the U.S. National Library of Medicine Medical Subject Headings (MeSH)