Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene .[ 5] [ 6] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000108669 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017132 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu L, Pohajdak B (September 1992). "Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7". Biochim. Biophys. Acta . 1132 (1): 75–8. doi :10.1016/0167-4781(92)90055-5 . PMID 1511013 . ^ Dixon B, Mansour M, Pohajdak B (April 1993). "Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization". Cytogenet. Cell Genet . 63 (1): 42–4. doi :10.1159/000133498 . PMID 8449036 . ^ a b "Entrez Gene: PSCD1 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)" .^ Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D" . J. Biol. Chem . 274 (14): 9744–51. doi :10.1074/jbc.274.14.9744 PMID 10092663 . ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (October 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins" . J. Biol. Chem . 273 (42): 27459–66. doi :10.1074/jbc.273.42.27459 PMID 9765275 . ^ Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W (June 2000). "Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1" . EMBO J . 19 (11): 2525–36. doi :10.1093/emboj/19.11.2525 . PMC 212768 PMID 10835351 . ^ Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (July 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)" . J. Biol. Chem . 275 (28): 21331–9. doi :10.1074/jbc.M909642199 PMID 10748148 .
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule" . Cell . 86 (2): 233–42. doi :10.1016/S0092-8674(00)80095-1 PMID 8706128 . S2CID 18390795 . Meacci E, Tsai SC, Adamik R, Moss J, Vaughan M (1997). "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor" . Proc. Natl. Acad. Sci. U.S.A . 94 (5): 1745–8. Bibcode :1997PNAS...94.1745M . doi :10.1073/pnas.94.5.1745 PMC 19987 PMID 9050849 . Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Nagel W, Zeitlmann L, Schilcher P, Geiger C, Kolanus J, Kolanus W (1998). "Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1" . J. Biol. Chem . 273 (24): 14853–61. doi :10.1074/jbc.273.24.14853 PMID 9614087 . Betz SF, Schnuchel A, Wang H, Olejniczak ET, Meadows RP, Lipsky BP, Harris EA, Staunton DE, Fesik SW (1998). "Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1" . Proc. Natl. Acad. Sci. U.S.A . 95 (14): 7909–14. Bibcode :1998PNAS...95.7909B . doi :10.1073/pnas.95.14.7909 PMC 20903 PMID 9653114 . Nagel W, Schilcher P, Zeitlmann L, Kolanus W (1998). "The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function" . Mol. Biol. Cell . 9 (8): 1981–94. doi :10.1091/mbc.9.8.1981 . PMC 25450 PMID 9693361 . Pacheco-Rodriguez G, Meacci E, Vitale N, Moss J, Vaughan M (1998). "Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain" . J. Biol. Chem . 273 (41): 26543–8. doi :10.1074/jbc.273.41.26543 PMID 9756891 . Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins" . J. Biol. Chem . 273 (42): 27459–66. doi :10.1074/jbc.273.42.27459 PMID 9765275 . Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D" . J. Biol. Chem . 274 (14): 9744–51. doi :10.1074/jbc.274.14.9744 PMID 10092663 . Pacheco-Rodriguez G, Patton WA, Adamik R, Yoo HS, Lee FJ, Zhang GF, Moss J, Vaughan M (1999). "Structural elements of ADP-ribosylation factor 1 required for functional interaction with cytohesin-1" . J. Biol. Chem . 274 (18): 12438–44. doi :10.1074/jbc.274.18.12438 PMID 10212218 . Venkateswarlu K, Gunn-Moore F, Tavaré JM, Cullen PJ (1999). "EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain". J. Cell Sci . 112 ( Pt 12) (12): 1957–65. doi :10.1242/jcs.112.12.1957 . PMID 10341214 . Ogasawara M, Kim SC, Adamik R, Togawa A, Ferrans VJ, Takeda K, Kirby M, Moss J, Vaughan M (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors" . J. Biol. Chem . 275 (5): 3221–30. doi :10.1074/jbc.275.5.3221 PMID 10652308 . Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)" . J. Biol. Chem . 275 (28): 21331–9. doi :10.1074/jbc.M909642199 PMID 10748148 . Lee SY, Mansour M, Pohajdak B (2000). "B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex". Exp. Cell Res . 256 (2): 515–21. doi :10.1006/excr.2000.4845 . PMID 10772823 . Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W (2000). "Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1" . EMBO J . 19 (11): 2525–36. doi :10.1093/emboj/19.11.2525 . PMC 212768 PMID 10835351 . Dierks H, Kolanus J, Kolanus W (2001). "Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain" . J. Biol. Chem . 276 (40): 37472–81. doi :10.1074/jbc.M101502200 PMID 11438522 . Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity" . Proc. Natl. Acad. Sci. U.S.A . 99 (5): 2625–9. Bibcode :2002PNAS...99.2625T . doi :10.1073/pnas.052712999 PMC 122398 PMID 11867758 .
