Prickle planar cell polarity protein 2

PRICKLE2
Identifiers
Aliases	PRICKLE2, EPM5, prickle planar cell polarity protein 2
External IDs	OMIM: 608501; MGI: 1925144; HomoloGene: 17889; GeneCards: PRICKLE2; OMA:PRICKLE2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	64,445,476 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	92,683,136 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; epithelium of colon; ; middle temporal gyrus; ; entorhinal cortex; ; Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 23; ; myometrium; ; endometrium;
	Top expressed in
	piriform cortex; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; Amygdala; ; primary motor cortex; ; anterior amygdaloid area; ; subiculum; ; hippocampus proper; ; olfactory tubercle; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding;
Cellular component	cytoplasm; nuclear membrane; membrane; nucleus;
Biological process	Wnt signaling pathway, planar cell polarity pathway;
	Sources:Amigo / QuickGO
Orthologs
	166336
	243548
	ENSG00000163637
	ENSMUSG00000030020
	Q7Z3G6
	Q80Y24
	NM_198859; NM_001370528
	NM_001081146; NM_001134459; NM_001134460; NM_001134461
	NP_942559; NP_001357457
	NP_001074615; NP_001127931; NP_001127932; NP_001127933; NP_001391015
	Wikidata
View/Edit Human	View/Edit Mouse

Prickle planar cell polarity protein 2 is a protein that in humans is encoded by the PRICKLE2 gene. ^[5]

Function

This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163637 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Prickle planar cell polarity protein 2". Retrieved 2018-02-20.

Katoh M, Katoh M (February 2003). "Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle". Int. J. Mol. Med. 11 (2): 249–56. doi:10.3892/ijmm.11.2.249. PMID 12525887.
Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S (January 2012). "Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation". Mol. Cell. Biol. 32 (1): 173–85. doi:10.1128/MCB.06320-11. PMC 3255712. PMID 22037766.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163637 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Prickle planar cell polarity protein 2". Retrieved 2018-02-20.

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Prickle planar cell polarity protein 2

Function

References

Further reading