Queen bee acid (10-hydroxy-2-decenoic acid or 10-HDA) is a fatty acid found in royal jelly.[1][2][3]
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| Names | |
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| Preferred IUPAC name
(2E)-10-Hydroxydec-2-enoic acid | |
Other names
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| MeSH | C055543 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C10H18O3 | |
| Molar mass | 186.251 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Queen bee acid is being investigated for its potential pharmacological activities. It promotes neurogenesis of neural stem/progenitor cells (cells capable of differentiating into neurons, astrocytes, or oligodendrocytes) in vitro.[4] In addition, queen bee acid has been reported to have in vitro anti-tumor, anti-biotic, immunomodulatory, estrogenic, neurogenic, and innate immune response modulating activities.[5]
In the United States, the Food and Drug Administration has taken legal action against companies that have used unfounded claims of health benefits to market royal jelly products.[6][7]
See also
editReferences
edit- ^ Ji, N; Yu, RG; Yang, QH; Yu, PH; Li, Y (Jul 1987). "[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography]". Zhong Yao Tong Bao. 12 (9): 28–31, 62. PMID 3449246.
- ^ Bloodworth, BC; Harn, CS; Hock, CT; Boon, YO (Jul–Aug 1995). "Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly" (PDF). Journal of AOAC International. 78 (4): 1019–23. doi:10.1093/jaoac/78.4.1019. PMID 7580313.
- ^ Genç, Mahmut; Aslan, Abdurrahman (1999). "Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography". Journal of Chromatography A. 839 (1–2): 265–268. doi:10.1016/S0021-9673(99)00151-X. PMID 10327631.
- ^ Hattori, Noriko; Nomoto, Hiroshi; Fukumitsu, Hidefumi; Mishima, Satoshi; Furukawa, Shoei (2007-01-01). "Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro". Biomedical Research. 28 (5): 261–266. doi:10.2220/biomedres.28.261. PMID 18000339.
- ^ Sugiyama, Tsuyoshi; Takahashi, Keita; Mori, Hiroshi (2012). "Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses". Endocrine, Metabolic & Immune Disorders Drug _targets. 12 (4): 368–376. doi:10.2174/187153012803832530. PMID 23061418.
- ^ "Federal Government Seizes Dozens of Misbranded Drug Products: FDA warned company about making medical claims for bee-derived products". Food and Drug Administration. Apr 5, 2010.
- ^ "Inspections, Compliance, Enforcement, and Criminal Investigations: Beehive Botanicals, Inc". Food and Drug Administration. March 2, 2007.
External links
edit- Royal Jelly Uses, Side Effects & Warnings, medically reviewed by Drugs.com on Sep 29, 2020. Written by Cerner Multum.
- Izuta, H.; Chikaraishi, Y.; Shimazawa, M.; Mishima, S.; Hara, H. (2007). "10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells". Evidence-Based Complementary and Alternative Medicine. 6 (4): 489–494. doi:10.1093/ecam/nem152. PMC 2781774. PMID 18955252.
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