Retinoblastoma-like protein 2

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.

RBL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XI9, 5C1D
Identifiers
Aliases	RBL2, P130, Rb2, retinoblastoma-like 2, RB transcriptional corepressor like 2, BRUWAG
External IDs	OMIM: 180203; MGI: 105085; HomoloGene: 4098; GeneCards: RBL2; OMA:RBL2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q12.2 Start 53,433,977 bp End 53,491,648 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C4|8 44.25 cM Start 91,796,685 bp End 91,850,472 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium superficial temporal artery epithelium of nasopharynx Achilles tendon lymph node cardia tonsil body of pancreas pylorus mucosa of paranasal sinus Top expressed in parotid gland muscle of thigh spermatid saccule medial head of gastrocnemius muscle submandibular gland stroma of bone marrow temporal muscle triceps brachii muscle thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding promoter-specific chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleolus extracellular exosome nucleus transcription regulator complex nucleoplasm cytosol chromatin Biological process regulation of transcription by RNA polymerase II regulation of cell cycle cell cycle regulation of transcription, DNA-templated transcription, DNA-templated regulation of lipid kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of gene expression negative regulation of transcription by RNA polymerase II chromatin organization regulation of mitotic cell cycle cell differentiation regulation of cell division negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5934 19651 Ensembl ENSG00000103479 ENSMUSG00000031666 UniProt Q08999 Q64700 RefSeq (mRNA) NM_005611 NM_001323608 NM_001323609 NM_001323610 NM_001323611 NM_001282000 NM_001282001 NM_011250 RefSeq (protein) NP_001310537 NP_001310538 NP_001310539 NP_001310540 NP_005602 NP_001268929 NP_001268930 NP_035380 Location (UCSC) Chr 16: 53.43 – 53.49 Mb Chr 8: 91.8 – 91.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Retinoblastoma-like protein 2 has been shown to interact with:

• BRCA1,
• BRF1
• C-Raf,
• Cyclin E1,
• Cyclin-dependent kinase 2,
• HDAC1,
• Prohibitin, and
• RBBP8.

See also

• Pocket protein family

Further reading

• Soprano KJ, Purev E, Vuocolo S, Soprano DR (Aug 2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid". Oncogene. 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753. S2CID 19893445.
• De Falco G, Giordano A (Aug 2006). "pRb2/p130: a new candidate for retinoblastoma tumor formation". Oncogene. 25 (38): 5333–40. doi:10.1038/sj.onc.1209614. PMID 16936755. S2CID 40396708.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 92 (6): 2403–7. Bibcode:1995PNAS...92.2403S. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
• Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Graña X, Klinga-Levan K, Knudson AG, Giordano A (Dec 1993). "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19". Oncogene. 8 (12): 3465–8. PMID 8247552.
• Li Y, Graham C, Lacy S, Duncan AM, Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
• Hannon GJ, Demetrick D, Beach D (Dec 1993). "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins". Genes & Development. 7 (12A): 2378–91. doi:10.1101/gad.7.12a.2378. PMID 8253384.
• Lavender P, Vandel L, Bannister AJ, Kouzarides T (Jun 1997). "The HMG-box transcription factor HBP1 is _targeted by the pocket proteins and E1A". Oncogene. 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.
• Lacy S, Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene. 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854. S2CID 26359262.
• Shao Z, Siegert JL, Ruppert S, Robbins PD (Jul 1997). "Rb interacts with TAF(II)250/TFIID through multiple domains". Oncogene. 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374.
• Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Molecular and Cellular Biology. 18 (5): 2748–57. doi:10.1128/mcb.18.5.2748. PMC 110654. PMID 9566894.
• Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. S2CID 11374970.
• Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F". Molecular and Cellular Biology. 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC 109088. PMID 9710587.
• Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
• Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10493–8. Bibcode:1998PNAS...9510493F. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
• Paramio JM, Laín S, Segrelles C, Lane EB, Jorcano JL (Aug 1998). "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation". Oncogene. 17 (8): 949–57. doi:10.1038/sj.onc.1202031. PMID 9747874. S2CID 21804961.
• Wang S, Ghosh RN, Chellappan SP (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Molecular and Cellular Biology. 18 (12): 7487–98. doi:10.1128/mcb.18.12.7487. PMC 109329. PMID 9819434.
• Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP (Mar 1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Molecular and Cellular Biology. 19 (3): 2400–7. doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.

External links

• RBL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.