SOX2OT

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SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies within one of the introns of SOX2OT.^[3] SOX2OT and SOX2DOT (an isoform of SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated with central nervous system structures in zebrafish and chicken embryonic brains, and is dynamically regulated during embryogenesis.^[4] SOX2OT may play a role in vertebrate development.^[4]

SOX2-OT

Identifiers

SOX2-OT, NCRNA00043, SOX2 overlapping transcript

External IDs

OMIM: 616338; GeneCards: SOX2-OT; OMA:SOX2-OT - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q26.33	Start	180,989,762 bp^[1]
Band	3q26.33	End	181,836,880 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

corpus callosum

subthalamic nucleus

inferior ganglion of vagus nerve

external globus pallidus

pars reticulata

C1 segment

Medulla Oblongata

Pons

superior vestibular nucleus

pars compacta

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More reference expression data

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Species

Human

Mouse


347689


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ENSG00000242808


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n a


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 3: 180.99 – 181.84 Mb

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PubMed search

^[2]

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View/Edit Human

See also

Long noncoding RNA

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000242808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fantes J, Ragge NK, Lynch SA, et al. (April 2003). "Mutations in SOX2 cause anophthalmia". Nat. Genet. 33 (4): 461–3. doi:10.1038/ng1120. PMID 12612584.
^ ^a ^b Amaral PP, Neyt C, Wilkins SJ, et al. (November 2009). "Complex architecture and regulated expression of the Sox2ot locus during vertebrate development". RNA. 15 (11): 2013–27. doi:10.1261/rna.1705309. PMC 2764477. PMID 19767420.

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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