SWAP70

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.

SWAP70
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DN6
Identifiers
Aliases	SWAP70, SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
External IDs	OMIM: 604762; MGI: 1298390; HomoloGene: 7557; GeneCards: SWAP70; OMA:SWAP70 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 9,664,077 bp End 9,752,993 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E3|7 57.7 cM Start 109,820,918 bp End 109,882,713 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon amniotic fluid sural nerve cartilage tissue visceral pleura lower lobe of lung parietal pleura epithelium of nasopharynx palpebral conjunctiva tibia Top expressed in mesenteric lymph nodes decidua spleen right lung lobe blood left lung lobe stroma of bone marrow calvaria lumbar spinal ganglion femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding calcium ion binding protein binding ATP binding cadherin binding Cellular component cell projection membrane plasma membrane cytoskeleton nucleus lamellipodium cytoplasm Biological process positive regulation of cytosolic calcium ion concentration positive regulation of mast cell chemotaxis negative regulation of peptidyl-serine dephosphorylation negative regulation of actin filament depolymerization actin filament bundle assembly regulation of protein localization regulation of actin polymerization or depolymerization somatic cell DNA recombination isotype switching positive regulation of actin filament bundle assembly negative regulation of cell-cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23075 20947 Ensembl ENSG00000133789 ENSMUSG00000031015 UniProt Q9UH65 Q6A028 RefSeq (mRNA) NM_001297714 NM_015055 NM_009302 RefSeq (protein) NP_001284643 NP_055870 NP_033328 Location (UCSC) Chr 11: 9.66 – 9.75 Mb Chr 7: 109.82 – 109.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
• Rapalus L, Minegishi Y, Lavoie A, et al. (2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency". Clin. Immunol. 101 (3): 270–5. doi:10.1006/clim.2001.5116. PMID 11726218.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hilpelä P, Oberbanscheidt P, Hahne P, et al. (2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells". Mol. Biol. Cell. 14 (8): 3242–53. doi:10.1091/mbc.E03-01-0043. PMC 181564. PMID 12925760.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling". J. Cell Sci. 119 (Pt 3): 500–7. doi:10.1242/jcs.02767. PMID 16418221.
• Kimbara N, Dohi N, Miyamoto M, et al. (2006). "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells". Microbiol. Immunol. 50 (3): 235–42. doi:10.1111/j.1348-0421.2006.tb03790.x. PMID 16547421. S2CID 85037572.
• Liu J, Li D, Cao B, et al. (2007). "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation". J. Histochem. Cytochem. 55 (7): 701–8. doi:10.1369/jhc.6A7151.2007. PMID 17371938.