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Selman Waksman

Selman Abraham Waksman (July 22, 1888 – August 16, 1973) was a Jewish American inventor, Nobel Prize laureate, biochemist and microbiologist whose research into the decomposition of organisms that live in soil enabled the discovery of streptomycin and several other antibiotics. A professor of biochemistry and microbiology at Rutgers University for four decades, he discovered several antibiotics (and introduced the modern sense of that word to name them), and he introduced procedures that have led to the development of many others. The proceeds earned from the licensing of his patents funded a foundation for microbiological research, which established the Waksman Institute of Microbiology located at the Rutgers University Busch Campus in Piscataway, New Jersey (USA). In 1952, he was awarded the Nobel Prize in Physiology or Medicine for "ingenious, systematic, and successful studies of the soil microbes that led to the discovery of streptomycin." Waksman and his foundation later were sued by Albert Schatz, one of his Ph.D. students and the discoverer of streptomycin, for minimizing Schatz's role in the discovery.[2]

Selman Waksman
Waksman in 1953
Born(1888-07-22)July 22, 1888
Nova Pryluka, Kyiv Governorate, Russian Empire (now Ukraine)
DiedAugust 16, 1973(1973-08-16) (aged 85)
Woods Hole, Massachusetts, US
CitizenshipUnited States
EducationRutgers University
University of California, Berkeley
SpouseDeborah B. Mitnik (died 1974)
ChildrenByron H. Waksman (1919–2012)[1]
AwardsAlbert Lasker Award for Basic Medical Research (1948)
Nobel Prize in Physiology or Medicine (1952)
Leeuwenhoek Medal (1950)
Scientific career
FieldsBiochemistry and Microbiology
Doctoral advisorT. Brailsford Robertson

In 2005, Selman Waksman was granted an ACS National Historic Chemical Landmark in recognition of the significant work of his lab in isolating more than 15 antibiotics, including streptomycin, which was the first effective treatment for tuberculosis.[3]

Early life and education

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Selman Waksman was born on July 22, 1888 (July 8 according to the old Russian calendar[4]), to Jewish parents, in Nova Pryluka, Kyiv Governorate, Russian Empire,[5] now Vinnytsia Oblast, Ukraine. He was the son of Fradia (London) and Jacob Waksman.[6] In 1910, shortly after receiving his diploma from the Fifth Gymnasium in Odesa, he immigrated to the United States and became a naturalized American citizen six years later.[7]

Waksman attended Rutgers College (now Rutgers University), where he graduated in 1915 with a Bachelor of Science in agriculture. He continued his studies at Rutgers, receiving a Master of Science the following year, in 1916. During his graduate study, he worked under J. G. Lipman at the New Jersey Agricultural Experiment Station at Rutgers performing research in soil bacteriology. Waksman spent some months in 1915–1916 at the United States Department of Agriculture in Washington, DC under Charles Thom, studying soil fungi.[8]: 44–48  He was appointed as a research fellow at the University of California, Berkeley, and in 1918 he was awarded his doctor of philosophy in biochemistry.

Career

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He joined the faculty at Rutgers University in the Department of Biochemistry and Microbiology.

At Rutgers, Waksman's team discovered several antibiotics, including actinomycin, clavacin, streptothricin, streptomycin, grisein, neomycin, fradicin, candicidin, candidin. Waksman co-discovered streptomycin with Albert Schatz. Streptomycin was the first effective drug against gram-negative bacteria[3] and the first antibiotic used to cure tuberculosis. Waksman is credited with coining the term antibiotics to describe antibacterials derived from other living organisms, for example penicillin, though the term was used by the French dermatologist François Henri Hallopeau, in 1871 to describe a substance opposed to the development of life.[citation needed]

In 1931, Waksman organized the division of Marine Bacteriology at the Woods Hole Oceanographic Institution (WHOI) in addition to his task at Rutgers.[6] He was appointed a marine bacteriologist there and served until 1942. He was elected a trustee at WHOI and finally a Life Trustee.

In 1951,[9] using half of his patent royalties, Waksman created the Waksman Foundation for Microbiology.[10] At a meeting of the board of trustees of the foundation, held in July 1951, he urged the building of a facility for work in microbiology, named the Waksman Institute of Microbiology, which is located on the Busch Campus of Rutgers University in Piscataway, New Jersey. The foundation's first president, Waksman, was succeeded in this position by his son, Byron H. Waksman, from 1970 to 2000.[citation needed]

Research

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Streptomycin

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Main article: Streptomycin

Waksman had been studying the Streptomyces family of organisms since his college student days and had, for a time, been studying the organism Streptomyces griseus. Streptomycin was isolated from S. griseus and found effective against tuberculosis by one of Waksman's graduate students, Albert Schatz.[11] These results were later confirmed by Elizabeth Bugie Gregory, whose name was also published on "Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria" with Schatz and Waksman.[12] However, Bugie's name was not on the second key paper in 1944, which was regarding the efficacy of streptomycin against tuberculosis in test tubes, as Schatz claimed Bugie was not involved with the experiment.[12] Bugie was also not given credit for her work on streptomycin, nor was she listed on the patent proposal, as she signed an affidavit stating that she did not have any contribution in discovering streptomycin.[13] This was submitted under an attorney of the Rutgers Research and Endowment Foundation.[citation needed]

Controversy

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See also: Albert Schatz (scientist) § Streptomycin controversy

The details and credit for the discovery of streptomycin and its usefulness as an antibiotic were strongly contested by Albert Schatz, leading to litigation in 1950.[14] However, it was possible that Waksman did not see Schatz's contribution as significantly as Schatz saw his contributions. Waksman noted that Schatz was away at the military in 1943, adding that he was only in the lab for three months and only played a small role in discovering streptomycin.[15][12] Waksman and Rutgers settled out of court with Schatz, resulting in financial remuneration and entitlement to "legal and scientific credit as co-discoverer of streptomycin."[16][17] Schatz was awarded $120,000 for patent rights and 3% of royalties.[18] The Lancet claimed that "the Nobel committee made a considerable mistake by failing to recognize Schatz's contribution."[19]

Systematic experiments to test several strains of antibiotics against several different disease organisms were underway in Waksman's laboratory at the time. Their classic approach was to explore a complete matrix with rows consisting of antibiotics and columns consisting of different diseases. The bacteria which produced the antibiotic streptomycin were discovered by Schatz in the farmland outside his lab and tested by him.[16] Waksman, however, eventually came to claim sole credit for the discovery.[citation needed]

The controversy of streptomycin between Waksman and Schatz brought to light the challenges of distributing credit for scientific research, discoveries, and patents.[2] It prompted schools and universities to become more involved in the patenting process and to have more regulations on how credit is dispersed. Schools would also provide clearer lines for each individual's role in a lab to minimize future litigations against the school.[2]

Neomycin

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Main article: Neomycin

Neomycin is derived from actinomycetes and was discovered by Waksman and Hubert A. Lechevalier, one of Waksman's graduate students. The discovery was published in the journal Science.[20]

Marine bacteria

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Waksman's research also examined the role of bacteria in marine systems, with a particular focus on the role of bacteria in nutrient cycles. Waksman examined the degradation of alginic acid,[21] cellulose,[22] and zooplankton.[23] Waksman, working with Cornelia Carey, Margaret Hotchkiss, Yvette Hardman, and Donald Johnston, conducted multiple studies on the actions of bacteria in marine systems which included quantifying the abundance[24] and viability of bacteria in seawater.,[25] examining the impact of copper on bacterial growth,[26] estimating the impact of bacterial activity on the nitrogen cycle,[27][28] and a separation of bacteria into groups based on habitat use in seawater, on plankton, or in the sediments.[29]

Other tributes involve anti-fouling paint for the Navy, the use of enzymes in laundry detergents, and the practice of Concord grape rootstock to safeguard French vineyards from fungal infections.[citation needed]

Awards and honors

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Waksman acquired many awards and honors, including the Nobel Prize in 1952; the Star of the Rising Sun granted to him by the emperor of Japan, and the rank of Commandeur in the French Légion d'honneur.[5][30][31] During his Nobel Prize award presentation, Waksman was called "one of the greatest benefactors to mankind," as the result of his discovery of streptomycin.[32] Schatz protested being left out of the award, even sending a letter to Gustaf VI Adolf, the King of Sweden, but the State did not have any influence over the Nobel Prize Committee's decision and they ruled that he was a mere lab assistant working under a scientist.[15][16]

The Selman A. Waksman Award in Microbiology of the National Academy of Sciences is given in his honor.[33]

Publications

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Selman Waksman was the author or co-author of over 400 scientific papers, as well as 28 books[5] and 14 scientific pamphlets.

  • Enzymes (1926)
  • Humus: origin, chemical composition, and importance in nature (1936, 1938)
  • Principles of Soil Microbiology (1927, 1932)
  • My Life with the Microbes (1954) (an autobiography)

Personal life

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Waksman was married to Deborah B. Mitnik. They had one son, Byron H. Waksman, M.D., who was an assistant professor at Harvard University Medical School, and Professor of Microbiology at Yale University Medical School.[6]

Selman Waksman died on August 16, 1973, at a Hyannis, Massachusetts, hospital and was interred at the Woods Hole Village Cemetery in Woods Hole, Massachusetts.[5]

See also

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References

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  1. ^ "Byron H. Waksman, M.D. (AAI '50) 1919–2012". The Journal of Immunology. 189 (8): 3783–3784. 2012. doi:10.4049/jimmunol.1290059. ISSN 0022-1767. S2CID 220253897.
  2. ^ a b c Kingston, William (2004-07-01). "Streptomycin, Schatz v. Waksman, and the balance of credit for discovery". Journal of the History of Medicine and Allied Sciences. 59 (3): 441–462. doi:10.1093/jhmas/jrh091. ISSN 0022-5045. PMID 15270337. S2CID 27465970.
  3. ^ a b "Selman Waksman and Antibiotics". National Historic Chemical Landmarks. American Chemical Society. Retrieved 2014-02-21.
  4. ^ "Selman Waksman and Antibiotics - Landmark". American Chemical Society. Retrieved 2022-10-03.
  5. ^ a b c d "The Foundation and Its History". waksman-foundation.org. Archived from the original on March 4, 2016. Retrieved January 11, 2007.
  6. ^ a b c "Selman A. Waksman - Biographical". nobelprize.org. Retrieved April 9, 2018.
  7. ^ (ru)// Виталий Орлов. Зельман Ваксман — открыватель препарата против туберкулеза // Я - Одессит, 24.09.2022
  8. ^ Ryan, Frank (1993). The forgotten plague: how the battle against tuberculosis was won—and lost. Boston: Little, Brown. ISBN 978-0316763806.
  9. ^ "Foundation History". Archived from the original on March 4, 2016.
  10. ^ "Waksman Foundation for Microbiology homepage". Archived from the original on January 11, 2016.
  11. ^ Andrew Jack (April 14, 2012). "Germ warfare". Financial Times.
  12. ^ a b c "The Forgotten Women of the Antibiotics Race". Lady Science. 22 July 2021. Retrieved 2021-12-21.
  13. ^ "Obiturary: Elizabeth Gregory / Did McCandless woman get a fair shake for the role in the discovery of streptomycin?". old.post-gazette.com. Archived from the original on 2021-11-29. Retrieved 2021-12-21.
  14. ^ "The Schatz v. Waksman Lawsuit – 1950". scc.rutgers.edu. Archived from the original on October 14, 2008.
  15. ^ a b Milton., Wainwright (1991). Streptomycin : discovery and resultant controversy. [Verlag nicht ermittelbar]. OCLC 1101806541.
  16. ^ a b c Pringle, Peter (June 11, 2012). "Notebooks Shed Light on a Discovery, and a Mentor's Betrayal". The New York Times. Retrieved June 11, 2012.
  17. ^ Mistiaen, Veronique (November 2, 2002). "Time, and the great healer". The Guardian. London. Retrieved April 13, 2010. The story of streptomycin – of scientific triumphs, all-too-human scientists and a long quest for justice – lies somewhere between these two men.
  18. ^ TIMES, Special to THE NEW YORK (1950-12-30). "Dr. Schatz Wins 3% of Royalty; Named Co-Finder of Streptomycin; KEY FIGURES IN STREPTOMYCIN DISCOVERY SUIT". The New York Times. ISSN 0362-4331. Retrieved 2022-10-03.
  19. ^ The Lancet Infectious Diseases (2005-11-01). "The Nobel cause". The Lancet Infectious Diseases. 5 (11): 665. doi:10.1016/S1473-3099(05)70245-0. ISSN 1473-3099. PMID 16253880.
  20. ^ Waksman, S. A.; Lechevalier, H. A. (1949-03-25). "Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms". Science. 109 (2830): 305–307. Bibcode:1949Sci...109..305W. doi:10.1126/science.109.2830.305. ISSN 0036-8075. PMID 17782716.
  21. ^ Waksman, S. A.; Carey, C. L.; Allen, M. C. (1934). "Bacteria Decomposing Alginic Acid". Journal of Bacteriology. 28 (2): 213–220. doi:10.1128/jb.28.2.213-220.1934. ISSN 0021-9193. PMC 533668. PMID 16559742.
  22. ^ Waksman, S. A.; Carey, C. (1926). "The Use of the Silica Gel Plate for Demonstrating the Occurrence and Abundance of Cellulose-Decomposing Bacteria". Journal of Bacteriology. 12 (2): 87–95. doi:10.1128/jb.12.2.87-95.1926. ISSN 0021-9193. PMC 374888. PMID 16559206.
  23. ^ Waksman, Selman A.; Carey, Cornelia L.; Reuszer, Herbert W. (1933-08-01). "Marine bacteria and their rôle in the cycle of life in the sea: i. decomposition of marine plant and animal residues by bacteria". The Biological Bulletin. 65 (1): 57–79. doi:10.2307/1537188. ISSN 0006-3185. JSTOR 1537188.
  24. ^ Waksman, S. A.; Carey, C. L. (1935). "Decomposition of Organic Matter in Sea Water by Bacteria: II. Influence of Addition of Organic Substances upon Bacterial Activities". Journal of Bacteriology. 29 (5): 545–561. doi:10.1128/jb.29.5.545-561.1935. ISSN 0021-9193. PMC 543620. PMID 16559809.
  25. ^ Waksman, S. A.; Hotchkiss, M. (1937). "Viability of Bacteria in Sea Water". Journal of Bacteriology. 33 (4): 389–400. doi:10.1128/jb.33.4.389-400.1937. ISSN 0021-9193. PMC 545103. PMID 16560007.
  26. ^ Waksman, Selman A.; Johnston, Donald B.; Carey, Cornelia A. (1943). "The effect of copper upon the development of bacteria in seawater and the isolation of specific bacteria" (PDF). Journal of Marine Research. 5 (2–06): 136–152.
  27. ^ Waksman, S. A.; Hotchkiss, M.; Carey, C. L.; Hardman, Y. (1938). "Decomposition of Nitrogenous Substances in Sea Water by Bacteria". Journal of Bacteriology. 35 (5): 477–486. doi:10.1128/jb.35.5.477-486.1938. ISSN 0021-9193. PMC 545432. PMID 16560120.
  28. ^ Waksman, Selman A.; Hotchkiss, Margaret; Carey, Cornelia L. (1933-10-01). "Marine bacteria and their rôle in the cycle of life in the sea: ii. bacteria concerned in the cycle of nitrogen in the sea". The Biological Bulletin. 65 (2): 137–167. doi:10.2307/1537170. ISSN 0006-3185. JSTOR 1537170.
  29. ^ Waksman, Selman A.; Reuszer, H. W.; Carey, Cornelia L.; Hotchkiss, Margaret; Renn, C. E. (1933-04-01). "Studies on the biology and chemistry of the Gulf of Maine : iii. bacteriological investigations of the seawater and marine bottoms". The Biological Bulletin. 64 (2): 183–205. doi:10.2307/1537228. ISSN 0006-3185. JSTOR 1537228.
  30. ^ "Dr. Selman Waksman". The Waksman Institute at Rutgers (No further authorship information available). Archived from the original on April 18, 2008. Retrieved January 17, 2008.
  31. ^ "The Nobel Prize in Physiology or Medicine 1952". www.nobelprize.org. Retrieved April 9, 2018.
  32. ^ "Nobelprize.org". www.nobelprize.org. Retrieved April 9, 2018.
  33. ^ "Selman A Walksman Award". Archived from the original on April 20, 2012. Retrieved July 29, 2012.
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