Simfibrate

Simfibrate
Clinical data
Trade names	Cholesolvin
Other names	3-{[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy}propyl 2-(4-chlorophenoxy)-2-methylpropanoate
ATC code	C10AB06 (WHO) ;
Identifiers
	IUPAC name Propane-1,3-diyl bis[2-(4-chlorophenoxy)-2-methylpropanoate];
CAS Number	14929-11-4;
PubChem CID	5217;
ChemSpider	5028 ;
UNII	L2R75RQX26;
KEGG	D01212 ;
CompTox Dashboard (EPA)	DTXSID8057647 ;
ECHA InfoCard	100.035.438
Chemical and physical data
Formula	C23H26Cl2O6
Molar mass	469.36 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2ccc(OC(C(=O)OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)(C)C)cc2;
	InChI InChI=1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 ; Key:JLRNKCZRCMIVKA-UHFFFAOYSA-N ;
	(verify)

Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia.^[1]^[2] The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.

References

^ Verma N (2016). "Introduction to Hyperlipidemia and its Treatment: A Review". International Journal of Current Pharmaceutical Research. 9: 6. doi:10.22159/ijcpr.2017v9i1.16616.
^ Olsson AG, Orö L, Rössner S (1974). "Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate". Atherosclerosis. 19 (3): 407–15. doi:10.1016/S0021-9150(74)80005-5. PMID 4364073.

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