GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000113595 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021712 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (Apr 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain" . The Journal of Biological Chemistry . 268 (12): 8801–7. doi :10.1016/S0021-9258(18)52945-8 PMID 8473324 . ^ a b "Entrez Gene: TRIM23 tripartite motif-containing 23" .^ a b Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments" . The EMBO Journal . 20 (9): 2140–51. doi :10.1093/emboj/20.9.2140 . PMC 125245 PMID 11331580 . ^ Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)" . The Journal of Biological Chemistry . 275 (28): 21331–9. doi :10.1074/jbc.M909642199 PMID 10748148 .
Vitale N, Moss J, Vaughan M (Mar 1996). "ARD1, a 64-kDa bifunctional protein containing an 18-kDa GTP-binding ADP-ribosylation factor domain and a 46-kDa GTPase-activating domain" . Proceedings of the National Academy of Sciences of the United States of America . 93 (5): 1941–4. Bibcode :1996PNAS...93.1941V . doi :10.1073/pnas.93.5.1941 PMC 39887 PMID 8700863 . Vitale N, Moss J, Vaughan M (Oct 1997). "Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor domain protein ARD1" . The Journal of Biological Chemistry . 272 (40): 25077–82. doi :10.1074/jbc.272.40.25077 PMID 9312116 . Vitale N, Moss J, Vaughan M (Jan 1998). "Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1)" . The Journal of Biological Chemistry . 273 (5): 2553–60. doi :10.1074/jbc.273.5.2553 PMID 9446556 . Vitale N, Horiba K, Ferrans VJ, Moss J, Vaughan M (Jul 1998). "Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus" . Proceedings of the National Academy of Sciences of the United States of America . 95 (15): 8613–8. Bibcode :1998PNAS...95.8613V . doi :10.1073/pnas.95.15.8613 PMC 21124 PMID 9671726 . Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)" . The Journal of Biological Chemistry . 275 (28): 21331–9. doi :10.1074/jbc.M909642199 PMID 10748148 . Vitale N, Ferrans VJ, Moss J, Vaughan M (Oct 2000). "Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1" . Molecular and Cellular Biology . 20 (19): 7342–52. doi :10.1128/MCB.20.19.7342-7352.2000 . PMC 86288 PMID 10982851 . Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments" . The EMBO Journal . 20 (9): 2140–51. doi :10.1093/emboj/20.9.2140 . PMC 125245 PMID 11331580 . Vichi A, Payne DM, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)" . Proceedings of the National Academy of Sciences of the United States of America . 102 (6): 1945–50. Bibcode :2005PNAS..102.1945V . doi :10.1073/pnas.0409800102 PMC 548593 PMID 15684077 .
