Talbutal

Talbutal
Clinical data
Other names	5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
ATC code	N05CA07 (WHO) ;
Legal status
Legal status	CA: Schedule IV; US: Schedule III;
Identifiers
	IUPAC name (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione;
CAS Number	115-44-6 ;
PubChem CID	8275;
DrugBank	DB00306 ;
ChemSpider	7976 ;
UNII	4YIR8202AX;
ChEMBL	ChEMBL1200802 ;
CompTox Dashboard (EPA)	DTXSID8023630 ;
ECHA InfoCard	100.003.719
Chemical and physical data
Formula	C11H16N2O3
Molar mass	224.260 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(C(C)CC)C\C=C;
	InChI InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16) ; Key:BJVVMKUXKQHWJK-UHFFFAOYSA-N ;
	(what is this?) (verify)

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.

Pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.^[1]

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl⁻ ionophore at the GABA_A receptor, increasing the duration of time for which the Cl⁻ ionophore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,^[1] and shock.

References

^ ^a ^b Mutschler E, Schäfer-Korting M (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.

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[Mutschler-1] Mutschler E, Schäfer-Korting M (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.

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