Talk:Neutralizing antibody

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 7 January 2020 and 12 March 2020. Further details are available on the course page. Student editor(s): Immcarle123.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 05:11, 17 January 2022 (UTC)

Article help

Here are a few things you need to do:

• Add categoriesY
• Add a pictureY
• Add an infobox or tableY
• Add more content, it cannot be a B-class with less than 100 words, aim for about 500 at least Y
• Keep up the use of referencesY

That's about it I think. You've made a brilliant start, so getting to that all important milestone shouldn't be to hard. Gaia Octavia Agrippa ^Talk | _Sign 13:20, 8 July 2009 (UTC)

Looking good. Now find the appropriate infobox and add a couple more paragraphs or another section. Gaia Octavia Agrippa ^Talk | _Sign 21:11, 22 July 2009 (UTC)

Congratulations! This is now a B-class article. You can expand it further and ask for help at Wikipedia:WikiProject Medicine to get it to an A-class article, or leave it as it is and start a new article. Then again you don't have to do either! Gaia Octavia Agrippa ^Talk | _Sign 20:27, 5 August 2009 (UTC)

Blocking antibody

Is this a synonym, or there is a difference? Staszek Lem (talk) 21:40, 24 April 2015 (UTC)

Merger proposal

See also: Wikipedia talk:WikiProject Medicine § Merger proposal: Merge Neutralisation into Neutralizing Antibody

I propose to merge Neutralisation (immunology) into Neutralizing antibody. Both articles are on exactly the same subject, namely neutralising antibodies. The neutralisation article contains important information on vaccination and Virus evasion that the neutralising antibody article could benefit from. Both articles are similar in size, but in my opinion the term neutralising antibody is the more used in order to refer to the phenomenon of neutralisation and therefore should be kept as the title of the article. As neutralising antibodies are currently heavily discussed in the media coverage of COVID-19, I think this merge is very important. --Huhny (talk) 12:22, 27 March 2020 (UTC)

@Immcarle123: What do you think about this? --Huhny (talk) 12:27, 27 March 2020 (UTC)

My idea for the structure and content of the article is as follows:

• Copy of sections Virus evasion of neutralizing antibodies, Vaccines, Treatment with neutralizing antibodies from Neutralisation (immunology) directly into this article. Maybe have Vaccines and Treatment as subsections under Medical uses of neutralizing antibodies.
• Parts of the section Viral infection and antibody response can be merged with the Mechanism section on this page. However, for my taste the text Viral infection and antibody response is a bit too broad as the topic is already covered (or should be covered) by other articles (e.g Humoral immunity, Viral replication)and can be linked. This text should only talk about the specific action of neutralising antibodies.
• The section Broadly-neutralizing antibodies needs to be revised and rewritten as at the moments it is filled with fragmented information.

--Huhny (talk) 13:07, 27 March 2020 (UTC)

I can't really speak to your idea, but I do want to add this. I EVENTUALLY made it to the "Neutralisation (immunology)" article because I was searching out the term "microneutralization" and "microneutralization assay." The Centers for Disease Control and Prevention make reference to this term in their testing guidance for the MERS coronavirus. As long as you all are proposing changes, I'd also recommend 1. adding a new redirect from "Microneutralization" to the final _target article and 2. add a blurb to the content about what that actually is. This source says "microneutralization simply means that the neutralization assay is done in a small format, such as a 96 well plate, instead of larger cell culture dishes," but I don't know if that is accurate. (This source leads me to believe readability and resolution would normally be at risk in typical neutralization, but advances in microneutralization have negated that risk?) Please consider this as well in any updates you all make. Thanks. Lostraven (talk) 16:16, 4 April 2020 (UTC)

OK, I found my answer on microneutralization here. I'm going to see if I can aesthetically integrate that information into the Neutralisation (immunology) article now. You can then carry it over to whatever endpoint you decide. Lostraven (talk) 16:39, 4 April 2020 (UTC)

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

There was no objection against the merge. The article Neutralisation (immunology) will be merged into Neutralizing antibody. Huhny (talk) 17:04, 27 April 2020 (UTC)

---

Proposal: Merging Neutralisation (immunology) into Neutralizing antibody

• Both articles are on exactly the same subject, namely neutralising antibodies and have the same content.
• The article Neutralizing antibody currently contains more information, it will therefore remain the main article.
• The term 'neutralisation in immunology always refers to the action of neutralising antibodies.
• The topics antibody-dependent enhancement and microneutralization will be added.
• A redirect from Neutralisation (immunology) to Neutralizing antibody will be created

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Additional references

I am planning to edit the article using the following resources:

Kelsoe, Garnett; Haynes, Barton F. (2017). "Host controls of HIV broadly neutralizing antibody development". Immunological Reviews. 275 (1): 79–88. doi:10.1111/imr.12508. ISSN 1600-065X. PMC 5479487. PMID 28133807.

McCoy, Laura E.; Burton, Dennis R. (2017). "Identification and specificity of broadly neutralizing antibodies against HIV". Immunological Reviews. 275 (1): 11–20. doi:10.1111/imr.12484. ISSN 1600-065X. PMC 5299474. PMID 28133814.

Dai, Lianpan; Wang, Qihui; Qi, Jianxun; Shi, Yi; Yan, Jinghua; Gao, George F. (2016). "Molecular basis of antibody-mediated neutralization and protection against flavivirus". IUBMB Life. 68 (10): 783–791. doi:10.1002/iub.1556. ISSN 1521-6551.

Sok, Devin; Burton, Dennis R. (2018-11). "Recent progress in broadly neutralizing antibodies to HIV". Nature Immunology. 19 (11): 1179–1188. doi:10.1038/s41590-018-0235-7. ISSN 1529-2916. Check date values in: |date= (help)

Corti, Davide; Lanzavecchia, Antonio (2013). "Broadly Neutralizing Antiviral Antibodies". Annual Review of Immunology. 31 (1): 705–742. doi:10.1146/annurev-immunol-032712-095916. PMID 23330954.

Bhiman, Jinal N.; Lynch, Rebecca M. (04 2017). "Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System". Current HIV/AIDS reports. 14 (2): 54–62. doi:10.1007/s11904-017-0352-1. ISSN 1548-3576. PMC 5401706. PMID 28349376. Check date values in: |date= (help)

Merge with neutralising antibody

See also: Talk:Neutralizing_antibody § Merger proposal

Could this page be merged with the article on neutralizing antibodies? This page essentially only talks about neutralising antibodies and the neutralising antibody page would benefit a lot from the information on this page.--Huhny (talk) 12:10, 27 March 2020 (UTC)